Add to ORKGThe discovery of genes involved in familial as well as sporadic forms of Parkinson disease (PD) constitutes an important milestone in understanding this disorder's pathophysiology and potential treatment. Among these genes, GBA1 is one of the most common and well-studied, but it is still unclear how mutations in GBA1 translate into an increased risk for developing PD. In this review, we provide an overview of the biochemical and structural relationship between GBA1 and PD to help understand the recent advances in the development of PD therapies intended to target this pathway
Mutations in the GBA gene that encodes the lysosomal enzyme β-glucocerebrosidase (GCase) are a major...
peer reviewedGiven the clear role of GBA in the pathogenesis of Parkinson's disease (PD) and its imp...
Parkinson’s disease (PD) is the second most common degenerative disorder. Although the disease...
The discovery of genes involved in familial as well as sporadic forms of Parkinson disease (PD) cons...
The GBA gene encodes for the lysosomal enzyme glucocerebrosidase (GCase), which maintains glycosphin...
Dysfunction of the endolysosomal system is implicated in the pathogenesis of both sporadic and famil...
Following the discovery of a higher than expected incidence of Parkinson Disease (PD) in Gaucher dis...
Heterozygous mutations of the GBA1 gene, encoding for lysosomal enzyme glucocerebrosidase (GCase), o...
GBA mutations are to date the most common genetic risk factor for Parkinson's disease. The GBA gene ...
GBA mutations are to date the most common genetic risk factor for Parkinson's disease. The GBA gene ...
The GBA gene encodes for the lysosomal enzyme glucocerebrosidase (GCase), which maintains glycosphin...
Background: Parkinson’s disease (PD) is a common neurodegenerative disorder mainly characterized by ...
This thesis focusses on the further unravelling of one of the mechanisms involved in developing Park...
Since its first description in the XIV century, the understanding of Parkinson disease (PD) has adv...
In the last years, lysosomal storage diseases appear as a bridge of knowledge between rare genetic i...
Mutations in the GBA gene that encodes the lysosomal enzyme β-glucocerebrosidase (GCase) are a major...
peer reviewedGiven the clear role of GBA in the pathogenesis of Parkinson's disease (PD) and its imp...
Parkinson’s disease (PD) is the second most common degenerative disorder. Although the disease...
The discovery of genes involved in familial as well as sporadic forms of Parkinson disease (PD) cons...
The GBA gene encodes for the lysosomal enzyme glucocerebrosidase (GCase), which maintains glycosphin...
Dysfunction of the endolysosomal system is implicated in the pathogenesis of both sporadic and famil...
Following the discovery of a higher than expected incidence of Parkinson Disease (PD) in Gaucher dis...
Heterozygous mutations of the GBA1 gene, encoding for lysosomal enzyme glucocerebrosidase (GCase), o...
GBA mutations are to date the most common genetic risk factor for Parkinson's disease. The GBA gene ...
GBA mutations are to date the most common genetic risk factor for Parkinson's disease. The GBA gene ...
The GBA gene encodes for the lysosomal enzyme glucocerebrosidase (GCase), which maintains glycosphin...
Background: Parkinson’s disease (PD) is a common neurodegenerative disorder mainly characterized by ...
This thesis focusses on the further unravelling of one of the mechanisms involved in developing Park...
Since its first description in the XIV century, the understanding of Parkinson disease (PD) has adv...
In the last years, lysosomal storage diseases appear as a bridge of knowledge between rare genetic i...
Mutations in the GBA gene that encodes the lysosomal enzyme β-glucocerebrosidase (GCase) are a major...
peer reviewedGiven the clear role of GBA in the pathogenesis of Parkinson's disease (PD) and its imp...
Parkinson’s disease (PD) is the second most common degenerative disorder. Although the disease...