Serotonin receptors: Implications for depression and its treatment

Trabajo presentado en el 14th World Congress of Biological Psychiatry, celebrado en Vancouver (Canadá), del 2 al 6 de junio de 2019Objective: Major depressive disorder (MDD) is a psychiatric syndrome with a high socioeconomic impact, due to its high prevalence and to the limited efficacy of treatments. Antidepressant efficacy depends, to a large extent, on the synaptic availability of serotonin (5-hydroxytryptamine; 5-HT) even for fast-acting strategies such as ketamine. However, blockade of the 5-HT transporter (SERT), as evoked by most antidepressant drugs (TCAs, SSRI, SNRI, etc.) is insufficient by itself to improve symptoms in many patients. The aim of the present talk is to describe the principal serotonergic mechanisms that facilitate or slow the antidepressant response.Support from SAF2015-68346-P is acknowledged