Glycerylphytate as an ionic crosslinker for 3D printing of multi-layered scaffolds with improved shape fidelity and biological features
- Mora-Boza, Ana
- Włodarczyk-Biegun, Małgorzata K.
- Campo, Aránzazu del
- Vázquez-Lasa, Blanca
- San Román, Julio
Publication date
January 2020
DOI Publisher
Royal Society of Chemistry (RSC) Journal
Biomaterials ScienceAbstract
The fabrication of intricate and long-term stable 3D polymeric scaffolds by a 3D printing technique is still a challenge. In the biomedical field, hydrogel materials are very frequently used because of their excellent biocompatibility and biodegradability, however the improvement of their processability and mechanical properties is still required. This paper reports the fabrication of dual crosslinked 3D scaffolds using a low concentrated (<10 wt%) ink of gelatin methacryloyl (GelMA)/chitosan and a novel crosslinking agent, glycerylphytate (G1Phy) to overcome the current limitations in the 3D printing field using hydrogels. The applied methodology consisted of a first ultraviolet light (UV) photopolymerization followed by a postprinti...
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