Analysis of radionuclide production in cyclotrons for application in positron emission tomography (PET)

[EN] The present work focuses on the analysis of nuclear reactions that can occur in a cyclotron for the generation of radionuclides compliant with the restrictions necessary for medical use in a PET. These radionuclides ought to meet some features, such as being positron emitters and having a half-life as short as possible, considering the times of processing and administration of the radiopharmaceutical. The radionuclides studied, 61Cu, 64Cu and 68Ga, meet these conditions. A commercial cyclotron has been modelled with an energy of 18 MeV for protons. Several simulations have been carried out with the model, using different materials as a target. The model validation has been done comparing results with experimental data from the literature.Ródenas Diago, J.; Jabaloyas, E. (2019). Analysis of radionuclide production in cyclotrons for application in positron emission tomography (PET). Journal of Radioanalytical and Nuclear Chemistry. 322(3):1691-1695. https://doi.org/10.1007/s10967-019-06903-0169116953223Alloni D, Prata M (2017) Appl Radiat Isot. https://doi.org/10.1016/j.apradiso.2017.07.031Alves F, Alves VHP, Do Carmo SJC, Neves ACB, Silva M, Abrunhosa AJ (2017) Mod Phys Lett A. https://doi.org/10.1142/s0217732317400132Costa P, Metello L, Alves F, Duarte Naia M (2018) Instruments. https://doi.org/10.3390/instruments2020008Qaim S (2017) Nuclear data for production and medical applications of radionuclides. Present Status Nucl Med Biol 44:31–49Anderson CJ, Ferdani R (2009) Cancer Biother Radiopharm. https://doi.org/10.1089/cbr.2009.0674Do Carmo SJC, Alves VHP, Alves F, Abrunhosa AJ (2017) Dalton Trans. https://doi.org/10.1039/c7dt01836cRomero Sanz E (2017) Desarrollo de un generador de 68Ge/68 Ga. Aplicaciones del 68 Ga en tomografía por emisión de positrones. Univ. Complutense de Madrid, Madrid, SpainInternational Atomic Energy Agency (2019) Gallium-68 cyclotron production, IAEA-TECDOC-1863. IAEA, ViennaMCNP6 User’s Manual (2018) Code Version 6.1, Los Alamos National Laboratory, Los Alamos, New MexicoKoning AJ, Rochman D, Sublet JC, Dzysiuk N, Fleming M, van der Marck S (2019) TENDL: complete nuclear data library for innovative nuclear science and technology. Nucl Data Sheets 155:1–55Sadeghi M, Kakavand T, Mokhtari L, Gholamzadeh Z (2009) Pramana J Phys. https://doi.org/10.1007/s12043-009-0029-42009