Small and Large Ribosomal Subunit Deficiencies Lead to Distinct Gene Expression Signatures that Reflect Cellular Growth Rate

In this issue of Molecular Cell, Cheng et al. report specific and dose-dependent gene expression changes resulting from decreased ribosome levels, including distinct gene expression signatures resulting from loss of genes encoding members of either the large or small ribosomal subunit.National Institutes of Health (U.S.) (Grant DP2-GM-119138)National Institutes of Health (U.S.) (Grant P50-GM-31535)Alfred P. Sloan Foundation (Investigator Award FG-2016–6229)Pew Charitable Trusts (Grant 00029624)National Human Genome Research Institute (U.S.). Centers of Excellence in Genomic Science (Grant P50 HG006193