Nectin-1 is an adhesion protein that also serves as a receptor for herpes simplex virus (HSV) to enter cells. In epithelial tissues nectin-1 proteins naturally bind to other nectin-1 molecules on adjacent cells to organize intercellular junctions. Recently, our lab showed that human nectin-1 also binds to the natural killer (NK) cell receptor CD96 (Holmes et al, PloS One, 2019). CD96 modulates the immune response of NK cells, which are part of the innate immune system of mammals. NK cells play an important role in eliminating virally infected cells and cancer cells. When HSV infection occurs, nectin-1 located at the cell surface becomes internalized by endocytosis. We hypothesize that HSV down-regulates nectin-1 from the surface of infected...
The poliovirus receptor (PVR) belongs to a large family of Ig molecules called nectins and nectin-li...
Skin keratinocytes represent a primary entry site for herpes simplex virus 1 (HSV-1) in vivo. The ce...
Nectin and nectin-like molecules (necls) are important regulators of intercellular junctions and tis...
Nectin-1 is an adhesion protein that also serves as a receptor for herpes simplex virus (HSV) to ent...
Regulation of Natural Killer (NK) cell activity is achieved by the integration of both activating an...
Regulation of Natural Killer (NK) cell activity is achieved by the integration of both activating an...
AbstractDuring herpes simplex virus (HSV) entry, membrane fusion occurs either on the cell surface o...
This study examines the effects of blocking the nectin-1 and Herpes Virus Entry Mediator (HVEM) rece...
AbstractEntry of herpes simplex virus (HSV) occurs either by fusion at the plasma membrane or by end...
AbstractThe site on nectin1 receptor required for herpes simplex virus (HSV) entry into the cell was...
The murine nectin1α (mNectin1α), a homolog of human nectin1α (hNectin1α, or PRR1, HveC), mediates th...
Human herpesvirus 6B (HHV-6B) is a T-lymphotropic virus and the etiological agent of exanthem subitu...
AbstractNectin-1 is a receptor for herpes simplex virus (HSV), a member of the immunoglobulin superf...
Human nectin1 (hNectin1), an adhesion molecule belonging to the nectin family of the immunoglobulin ...
The cellular proteins nectin-1 and herpesvirus entry mediator (HVEM) can both mediate the entry of h...
The poliovirus receptor (PVR) belongs to a large family of Ig molecules called nectins and nectin-li...
Skin keratinocytes represent a primary entry site for herpes simplex virus 1 (HSV-1) in vivo. The ce...
Nectin and nectin-like molecules (necls) are important regulators of intercellular junctions and tis...
Nectin-1 is an adhesion protein that also serves as a receptor for herpes simplex virus (HSV) to ent...
Regulation of Natural Killer (NK) cell activity is achieved by the integration of both activating an...
Regulation of Natural Killer (NK) cell activity is achieved by the integration of both activating an...
AbstractDuring herpes simplex virus (HSV) entry, membrane fusion occurs either on the cell surface o...
This study examines the effects of blocking the nectin-1 and Herpes Virus Entry Mediator (HVEM) rece...
AbstractEntry of herpes simplex virus (HSV) occurs either by fusion at the plasma membrane or by end...
AbstractThe site on nectin1 receptor required for herpes simplex virus (HSV) entry into the cell was...
The murine nectin1α (mNectin1α), a homolog of human nectin1α (hNectin1α, or PRR1, HveC), mediates th...
Human herpesvirus 6B (HHV-6B) is a T-lymphotropic virus and the etiological agent of exanthem subitu...
AbstractNectin-1 is a receptor for herpes simplex virus (HSV), a member of the immunoglobulin superf...
Human nectin1 (hNectin1), an adhesion molecule belonging to the nectin family of the immunoglobulin ...
The cellular proteins nectin-1 and herpesvirus entry mediator (HVEM) can both mediate the entry of h...
The poliovirus receptor (PVR) belongs to a large family of Ig molecules called nectins and nectin-li...
Skin keratinocytes represent a primary entry site for herpes simplex virus 1 (HSV-1) in vivo. The ce...
Nectin and nectin-like molecules (necls) are important regulators of intercellular junctions and tis...