Iodothyronine deiodinases (Dios) are involved in the regioselective removal of iodine from thyroid hormones (THs). Deiodination is essential to maintain TH homeostasis, and disruption can have detrimental effects. Halogen bonding (XB) to the selenium of the selenocysteine (Sec) residue in the Dio active site has been proposed to contribute to the mechanism for iodine removal. Polybrominated diphenyl ethers (PBDEs) and polychlorinated biphenyls (PCBs) are known disruptors of various pathways of the endocrine system. Experimental evidence shows PBDEs and their hydroxylated metabolites (OH-BDEs) can inhibit Dio, while data regarding PCB inhibition are limited. These xenobiotics could inhibit Dio activity by competitively binding to the active ...
The monodeiodination of the prohormone thyroxine (T4) to the biologically active hormone 3,5,3'-trii...
The deiodination of [125I]-4-iodobiphenyl, [125I]-4-iodonitrobenzene and [125I]-4-iodoaniline was i...
Halogen bonding (XB) is an attractive interaction between a halogen atom and an electron donor. Alth...
Halogen bonding (XB) is a potential mechanism for the inhibition of the thyroid-activating/deactivat...
Thyroid hormones (THs) in mammalian tissues are crucial for development and maintaining metabolic ho...
Thyroid hormones (THs) are key players in the endocrine system and play pivotal roles in carbohydrat...
Halogen bonding is a noncovalent interaction that continues to garner interest among the scientific ...
Iodothyronine deiodinases (Dios) are important selenoproteins that control the concentration of the ...
Iodothyronine deiodinases (IDs) are mammalian selenoenzymes that catalyze the conversion of thyroxin...
The type1 iodothyronine deiodinase (1D-1) in liver and kidney converts the L-thyroxine (T4), a proho...
Iodothyronine deiodinases (IDs) are mammalian selenoenzymes that play an important role in the activ...
Iodothyronamines (TAMs) are endogenous thyroid hormone (TH) metabolites, which are proposed to be bi...
Iodothyronine deiodinases (IDs) are mammalian selenoenzymes that catalyze the conversion of thyroxin...
Iodotyrosine deiodinase (IYD) catalyzes deiodination of mono- and diiodotyrosines (I-Tyr and I2-Tyr)...
Mammalian selenoenzymes, iodothyronine deiodinases (DIOs), catalyze the tyrosyl and phenolic ring de...
The monodeiodination of the prohormone thyroxine (T4) to the biologically active hormone 3,5,3'-trii...
The deiodination of [125I]-4-iodobiphenyl, [125I]-4-iodonitrobenzene and [125I]-4-iodoaniline was i...
Halogen bonding (XB) is an attractive interaction between a halogen atom and an electron donor. Alth...
Halogen bonding (XB) is a potential mechanism for the inhibition of the thyroid-activating/deactivat...
Thyroid hormones (THs) in mammalian tissues are crucial for development and maintaining metabolic ho...
Thyroid hormones (THs) are key players in the endocrine system and play pivotal roles in carbohydrat...
Halogen bonding is a noncovalent interaction that continues to garner interest among the scientific ...
Iodothyronine deiodinases (Dios) are important selenoproteins that control the concentration of the ...
Iodothyronine deiodinases (IDs) are mammalian selenoenzymes that catalyze the conversion of thyroxin...
The type1 iodothyronine deiodinase (1D-1) in liver and kidney converts the L-thyroxine (T4), a proho...
Iodothyronine deiodinases (IDs) are mammalian selenoenzymes that play an important role in the activ...
Iodothyronamines (TAMs) are endogenous thyroid hormone (TH) metabolites, which are proposed to be bi...
Iodothyronine deiodinases (IDs) are mammalian selenoenzymes that catalyze the conversion of thyroxin...
Iodotyrosine deiodinase (IYD) catalyzes deiodination of mono- and diiodotyrosines (I-Tyr and I2-Tyr)...
Mammalian selenoenzymes, iodothyronine deiodinases (DIOs), catalyze the tyrosyl and phenolic ring de...
The monodeiodination of the prohormone thyroxine (T4) to the biologically active hormone 3,5,3'-trii...
The deiodination of [125I]-4-iodobiphenyl, [125I]-4-iodonitrobenzene and [125I]-4-iodoaniline was i...
Halogen bonding (XB) is an attractive interaction between a halogen atom and an electron donor. Alth...