This body of work draws on parallels between the pathogenesis of rheumatoid arthritis (RA) and atherosclerosis. The pathogenesis and genetic basis of both diseases are described and compared. I describe how a polymorphism of the CX3CR1 gene, which has been shown to have a protective association against atherosclerosis, is shown to have has a similar protective association against RA. Using immunohistochemistry and confocal microscopy, I demonstrate that monocytes co-localise with CX3CR1 in human RA synovium, providing further evidence of the chemotactic effects between monocytes and the FKN/CX3CR1 axis and the significance of CX3CR1 in RA pathogenesis. Finally, I describe an association between seropositive RA and soluble Glycoprotein VI (s...
Atherosclerosis has been categorized as an inflammatory disorder, with similar chronic inflammatory ...
Objectives: This study, developed within the Innovative Medicines Initiative Joint Undertaking proje...
Cardiovascular disease (CVD) is the commonest cause of death in patients with rheumatoid arthritis (...
In the last decades a large amount of evidences linked rheumatoid arthritis (RA) to atherosclerosis....
In the last decades a large amount of evidence linked rheumatoid arthritis (RA) to atherosclerosis. ...
Substantial epidemiological data identified cardiovascular (CV) diseases as a main cause of mortalit...
Rheumatoid arthritis is a chronic inflammatory disease. Cardiovascular events are the most important...
Copyright © 2012 Lorenzo Cavagna et al. This is an open access article distributed under the Creativ...
Increased morbidity and mortality in patients with rheumatoid arthritis (RA) is largely associated w...
Rheumatoid arthritis is a chronic inflammatory disease. Cardiovascular events are the most important...
Cardiovascular (CV) disease is increased in patients with chronic inflammatory disease, including rh...
RA is characterized by a systemic inflammatory state, in which immune cells and soluble mediators pl...
Copyright © 2012 Miguel A. González-Gay et al. This is an open access article distributed under the...
Cardiovascular (CV) disease is the most common cause of premature mortality in patients with rheumat...
Objectives: This study, developed within the Innovative Medicines Initiative Joint Undertaking proje...
Atherosclerosis has been categorized as an inflammatory disorder, with similar chronic inflammatory ...
Objectives: This study, developed within the Innovative Medicines Initiative Joint Undertaking proje...
Cardiovascular disease (CVD) is the commonest cause of death in patients with rheumatoid arthritis (...
In the last decades a large amount of evidences linked rheumatoid arthritis (RA) to atherosclerosis....
In the last decades a large amount of evidence linked rheumatoid arthritis (RA) to atherosclerosis. ...
Substantial epidemiological data identified cardiovascular (CV) diseases as a main cause of mortalit...
Rheumatoid arthritis is a chronic inflammatory disease. Cardiovascular events are the most important...
Copyright © 2012 Lorenzo Cavagna et al. This is an open access article distributed under the Creativ...
Increased morbidity and mortality in patients with rheumatoid arthritis (RA) is largely associated w...
Rheumatoid arthritis is a chronic inflammatory disease. Cardiovascular events are the most important...
Cardiovascular (CV) disease is increased in patients with chronic inflammatory disease, including rh...
RA is characterized by a systemic inflammatory state, in which immune cells and soluble mediators pl...
Copyright © 2012 Miguel A. González-Gay et al. This is an open access article distributed under the...
Cardiovascular (CV) disease is the most common cause of premature mortality in patients with rheumat...
Objectives: This study, developed within the Innovative Medicines Initiative Joint Undertaking proje...
Atherosclerosis has been categorized as an inflammatory disorder, with similar chronic inflammatory ...
Objectives: This study, developed within the Innovative Medicines Initiative Joint Undertaking proje...
Cardiovascular disease (CVD) is the commonest cause of death in patients with rheumatoid arthritis (...