Patients infected with the life-threatening, methicillin-resistant, human pathogen Staphylococcus aureus (MRSA) can be treated only with antibiotics of last resort. The development of a vaccine as an alternative to antibiotics is therefore of great clinical importance to fight MRSA. Based on a S. aureus proteome screen with S. aureus specific human antiserum, novel surface-associated proteins were identified as vaccine candidates. Proto-porphyrinogen oxidase (pOxi), Triosephosphate isomerase (Triiso) and the hypo-thetical protein 2160 (hp2160) provided protection in a murine sepsis model upon active immunization. Monoclonal antibodies (moAbs) against these target proteins were generated of which three demonstrated significant, repetitive, e...
Enterotoxigenic Escherichia coli (ETEC) infections are a major cause of morbidity and mortality amon...
Abstract: Background: Malaria is one of the most devastating diseases with lethal outcome of more ...
Clinical findings have linked multiple risk factors and associated pathologies to Alzheimer\''s dise...
Dendritic cells play a pivotal role in antigen presentation and adaptive immune response activation....
T cells recognizing myelin auto-antigens penetrate into the CNS to induce inflammatory autoimmune di...
In their natural environment up to 99% of all microorganisms are assumed to live in microbial aggreg...
Influenza A virus infections are common all over the world and cause substantial damage on health an...
Cancer is one of the leading causes of death worldwide. In order to improve current cancer treatment...
Legionella pneumophila (L.p.) is a gram-negative, intracellular pathogen and a common cause of seve...
Owing to the development of antibiotic resistance in microorganisms, new anti-microbial and anti-inf...
In the present study the mechanisms leading to acquired chemoresistance, as well as new treatment s...
The transmission of influenza A viruses from avian to other species involves numerous adaptive proce...
GBMs have proven to be a major pathology with vast infiltration potential and extreme chemo- and rad...
Natural killer (NK) cells are important effectors of innate immune responses providing cellular immu...
Glioblastoma multiforme (GBM) is the most frequent and aggressive intracranial tumour in humans. The...
Enterotoxigenic Escherichia coli (ETEC) infections are a major cause of morbidity and mortality amon...
Abstract: Background: Malaria is one of the most devastating diseases with lethal outcome of more ...
Clinical findings have linked multiple risk factors and associated pathologies to Alzheimer\''s dise...
Dendritic cells play a pivotal role in antigen presentation and adaptive immune response activation....
T cells recognizing myelin auto-antigens penetrate into the CNS to induce inflammatory autoimmune di...
In their natural environment up to 99% of all microorganisms are assumed to live in microbial aggreg...
Influenza A virus infections are common all over the world and cause substantial damage on health an...
Cancer is one of the leading causes of death worldwide. In order to improve current cancer treatment...
Legionella pneumophila (L.p.) is a gram-negative, intracellular pathogen and a common cause of seve...
Owing to the development of antibiotic resistance in microorganisms, new anti-microbial and anti-inf...
In the present study the mechanisms leading to acquired chemoresistance, as well as new treatment s...
The transmission of influenza A viruses from avian to other species involves numerous adaptive proce...
GBMs have proven to be a major pathology with vast infiltration potential and extreme chemo- and rad...
Natural killer (NK) cells are important effectors of innate immune responses providing cellular immu...
Glioblastoma multiforme (GBM) is the most frequent and aggressive intracranial tumour in humans. The...
Enterotoxigenic Escherichia coli (ETEC) infections are a major cause of morbidity and mortality amon...
Abstract: Background: Malaria is one of the most devastating diseases with lethal outcome of more ...
Clinical findings have linked multiple risk factors and associated pathologies to Alzheimer\''s dise...