Evaluation of white sweet potato tube-feeding formula in elderly diabetic patients: a randomized controlled trial

White sweet potato;Type 2 diabetes mellitus; Tube feeding;Enteral nutritionBackground Elderly people with type 2 diabetes mellitus (T2DM) have an increased risk of diabetes-related microvascular and macrovascular complications, thus diabetic patients with a functioning gastrointestinal tract but without sufficient oral intake require enteral nutrition (EN) formulas to control blood glucose. White sweet potato (WSP) was a kind of sweet potato could provide a healthy carbohydrate source to EN formula. The aim of this study was to examine at risk of malnutrition T2DM patients whether a WSP-EN would attenuate glucose response and elevate nutritional index compared to a standard polymeric formulas. Methods In this randomized, parallel, placebo-controlled, pilot clinical trial to investigate the effects of EN with WSP on aged residents with T2DM in long-term care institutions. In total, 54 eligible participants were randomly assigned to either the non-WSP-EN or WSP-EN group. For 60 days, the WSP-EN group received a WSP formula through nasogastric tube via a stoma with a large-bore syringe. The participants received EN of standard polymeric formulas without WSP in the non-WSP-EN group. Results The body weight, body mass index, Mini Nutritional Assessment score, and Geriatric Nutritional Risk Index were significantly higher in the WSP-EN group (p < 0.05). Moreover, the WSP-EN intervention reduced glycated hemoglobin levels (6.73% +/- 1.47% vs. 6.40% +/- 1.16%), but increased transferrin (223.06 +/- 38.85 vs. 245.85 +/- 46.08 mg/dL), high-density lipoprotein cholesterol (42.13 +/- 10.56 vs. 44.25 +/- 8.43 mg/dL), and vitamin A (2.45 +/- 0.77 vs 2.74 +/- 0.93 mu M) levels (p < 0.05). In addition, there was no important side effects including gastrointestinal intolerance with prescribed doses in our WSP-EN treated patients when compared with control ones. Conclusions The results suggest WSP incorporated into enteral formulas can improve nutrition status and glycemic control in elderly diabetic patients