peer reviewedProlonged cell survival occur through the expression of specific protein isoforms generated by alternate splicing of mRNA precursors in cancer cells. How alternate splicing regulates tumor development and resistance to targeted therapies in cancer remain poorly understood. Here we show that RNF113A, whose loss-of-function causes the X-linked trichothiodystrophy, is overexpressed in lung cancer and protects from Cisplatin-dependent cell death. RNF113A is a RNA-binding protein which regulates the splicing of multiple candidates involved in cell survival. RNF113A deficiency triggers cell death upon DNA damage through multiple mechanisms, including apoptosis via the destabilization of the prosurvival protein MCL-1, ferroptosis due ...
Since early in evolutionary history, alternative RNA splicing has been an important method for metaz...
Acute myeloid leukemia (AML) is the most common form of acute leukaemia and has the highest mortalit...
Splicing factors (SFs) act in dynamic macromolecular complexes to modulate RNA processing. To unders...
Alternative splicing is a tightly regulated process whereby non-coding sequences of pre-mRNA are rem...
Alternative splicing promotes proteome diversity by using limited number of genes, a key control poi...
SummaryRNA binding proteins and signaling components control the production of pro-death and pro-sur...
Splicing alterations have been widely documented in tumors where the proliferation and dissemination...
Free PMC Article: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5793162/Aberrant profiles of pre-mRNA...
Mutations causing aberrant splicing are frequently implicated in human diseases including cancer. He...
Genomic characterization of cancer subtypes became a major research goal worldwide after the release...
Alterations in RNA splicing are frequent in human tumors. Two recent studies of lymphoma and breast ...
Alternative splicing allows for the expression of multiple RNA and protein isoforms from one gene, m...
The reactivation of telomerase in cancer cells remains incompletely understood. The catalytic compon...
© 2018 by the authors. Licensee MDPI, Basel, Switzerland. Over 95% of human genes are alternatively ...
Summary: Hotspot mutations in splicing factor genes have been recently reported at high frequency in...
Since early in evolutionary history, alternative RNA splicing has been an important method for metaz...
Acute myeloid leukemia (AML) is the most common form of acute leukaemia and has the highest mortalit...
Splicing factors (SFs) act in dynamic macromolecular complexes to modulate RNA processing. To unders...
Alternative splicing is a tightly regulated process whereby non-coding sequences of pre-mRNA are rem...
Alternative splicing promotes proteome diversity by using limited number of genes, a key control poi...
SummaryRNA binding proteins and signaling components control the production of pro-death and pro-sur...
Splicing alterations have been widely documented in tumors where the proliferation and dissemination...
Free PMC Article: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5793162/Aberrant profiles of pre-mRNA...
Mutations causing aberrant splicing are frequently implicated in human diseases including cancer. He...
Genomic characterization of cancer subtypes became a major research goal worldwide after the release...
Alterations in RNA splicing are frequent in human tumors. Two recent studies of lymphoma and breast ...
Alternative splicing allows for the expression of multiple RNA and protein isoforms from one gene, m...
The reactivation of telomerase in cancer cells remains incompletely understood. The catalytic compon...
© 2018 by the authors. Licensee MDPI, Basel, Switzerland. Over 95% of human genes are alternatively ...
Summary: Hotspot mutations in splicing factor genes have been recently reported at high frequency in...
Since early in evolutionary history, alternative RNA splicing has been an important method for metaz...
Acute myeloid leukemia (AML) is the most common form of acute leukaemia and has the highest mortalit...
Splicing factors (SFs) act in dynamic macromolecular complexes to modulate RNA processing. To unders...