Genome-wide association study in two cohorts from a multi-generational mouse advanced intercross line highlights the difficulty of replication due to study-specific heterogeneity

Genome-wide association of multiple complex traits in outbred mice by ultra low-coverage sequencing

Nicod, Jérôme
Davies, Robert W.
Cai, Na
Hassett, Carl
Goodstadt, Leo
Cosgrove, Cormac
Yee, Benjamin K.
Lionikaite, Vikte
McIntyre, Rebecca E.
Remme, Carol Ann
Lodder, Elisabeth M.
Gregory, Jennifer S.
Hough, Tertius
Joynson, Russell
Phelps, Hayley
Nell, Barbara
Rowe, Clare
Wood, Joe
Walling, Alison
Bopp, Nasrin
Bhomra, Amarjit
Hernandez-Pliego, Polinka
Callebert, Jacques
Aspden, Richard M.
Talbot, Nick P.
Robbins, Peter A.
Harrison, Mark
Fray, Martin
Launay, Jean-Marie
Pinto, Yigal M.
Blizard, David A.
Bezzina, Connie R.
Adams, David J.
Franken, Paul
Weaver, Tom
Wells, Sara
Brown, Steve D. M.
Potter, Paul K.
Klenerman, Paul
Lionikas, Arimantas
Mott, Richard
Flint, Jonathan

November 2016

The authors wish to acknowledge excellent technical assistance from A. Kurioka, L. Swadling, C. de L...

Assessing the prospects of genome-wide association studies performed in inbred mice.

Su, W L
Sieberts, S K
Kleinhanz, R R
Lux, K
Millstein, J
Molony, C
Schadt, E E

January 2010

The remarkable success in mapping genes linked to a number of disease traits using genome-wide assoc...

Genome wide association analysis in a mouse advanced intercross line.

Gonzales, Natalia M
Seo, Jungkyun
Hernandez Cordero, Ana I
St Pierre, Celine L
Gregory, Jennifer S
Distler, Margaret G
Abney, Mark
Canzar, Stefan
Lionikas, Arimantas
Palmer, Abraham A

December 2018

The LG/J x SM/J advanced intercross line of mice (LG x SM AIL) is a multigenerational outbred popula...

Genome-Wide Association Study in Two Cohorts from a Multi-generational Mouse Advanced Intercross Line Highlights the Difficulty of Replication Due to Study-Specific Heterogeneity

Xinzhu Zhou
Celine L. St. Pierre
Natalia M. Gonzales
Jennifer Zou
Riyan Cheng
Apurva S. Chitre
Greta Sokoloff
Abraham A. Palmer

March 2020

There has been extensive discussion of the “Replication Crisis” in many fields, including genome-wid...

Genome-Wide Association Study in Two Cohorts from a Multi-generational Mouse Advanced Intercross Line Highlights the Difficulty of Replication Due to Study-Specific Heterogeneity.

Zhou, Xinzhu
St Pierre, Celine L
Gonzales, Natalia M
Zou, Jennifer
Cheng, Riyan
Chitre, Apurva S
Sokoloff, Greta
Palmer, Abraham A

March 2020

There has been extensive discussion of the "Replication Crisis" in many fields, including genome-wid...

Genome-wide Association Discovery, Replication, and Validation in Mouse Models

Zhou, Xinzhu

January 2020

The “replication crisis” has highlighted the apparent lack of replication across scientific fields. ...

Genome wide association analysis in a mouse advanced intercross line

Gonzales, Natalia M.
Seo, Jungkyun
Cordero, Ana I. Hernandez
St Pierre, Celine L.
Gregory, Jennifer S.
Distler, Margaret G.
Abney, Mark
Canzar, Stefan
Lionikas, Arimantas
Palmer, Abraham A.

January 2018

The LG/J x SM/J advanced intercross line of mice (LG x SM AIL) is a multigenerational outbred popula...

Analysis of independent cohorts of outbred CFW mice reveals novel loci for behavioral and physiological traits and identifies factors determining reproducibility

Zou, J
Gopalakrishnan, S
Parker, CC
Nicod, J
Mott, R
Cai, N
Lionikas, A
Davies, RW
Palmer, AA
Flint, J

November 2021

Combining samples for genetic association is standard practice in human genetic analysis of complex ...

Genome-wide association studies and the problem of relatedness among advanced intercross lines and other highly recombinant populations

Cheng, Riyan
Lim, Jackie E
Samocha, Kaitlin E.
Sokoloff, Greta
Abney, Mark
Skol, Andrew D
Palmer, Abraham A

February 2016

Model organisms offer many advantages for the genetic analysis of complex traits. However, identific...

Genome-wide association studies in mice.

Flint, J
Eskin, E

January 2012

Genome-wide association studies (GWASs) have transformed the field of human genetics and have led to...

Genome-wide association of multiple complex traits in outbred mice by ultra-low-coverage sequencing

Nicod, J
Davies, RW
Cai, N
Hassett, C
Goodstadt, L
Cosgrove, C
Yee, BK
Lionikaite, V
McIntyre, RE
Remme, CA
Lodder, EM
Gregory, JS
Hough, T
Joynson, R
Phelps, H
Nell, B
Rowe, C
Wood, J
Walling, A
Bopp, N
Bhomra, A
Hernandez-Pliego, P
Callebert, J
Aspden, RM
Talbot, NP
Robbins, PA
Harrison, M
Fray, M
Launay, JM
Pinto, YM
Blizard, DA
Bezzina, CR
Adams, DJ
Franken, P
Weaver, T
Wells, S
Brown, SD
Potter, PK
Klenerman, P
Lionikas, A
Mott, R
Flint, J

August 2016

Two bottlenecks impeding the genetic analysis of complex traits in rodents are access to mapping pop...

Analysis of independent cohorts of outbred CFW mice reveals novel loci for behavioral and physiological traits and identifies factors determining reproducibility

Zou, Jennifer
Gopalakrishnan, Shyam
Parker, Clarissa
Nicod, Jerome
Mott, Richard
Cai, Na
Lionikas, Arimantas
Davies, Robert
Palmer, Abraham
Flint, Jonathan

October 2021

Combining samples for genetic association is standard practice in human genetic analysis of complex ...

Genetic analysis of complex traits in the emerging Collaborative Cross

Aylor, David L.
Valdar, William
Foulds-Mathes, Wendy
Buus, Ryan J.
Verdugo, Ricardo A.
Baric, Ralph S.
Ferris, Martin T.
Frelinger, Jeff A.
Heise, Mark
Frieman, Matt B.
Gralinski, Lisa E.
Bell, Timothy A.
Didion, John D.
Hua, Kunjie
Nehrenberg, Derrick L.
Powell, Christine L.
Steigerwalt, Jill
Xie, Yuying
Kelada, Samir N.P.
Collins, Francis S.
Yang, Ivana V.
Schwartz, David A.
Branstetter, Lisa A.
Chesler, Elissa J.
Miller, Darla R.
Spence, Jason
Liu, Eric Yi
McMillan, Leonard
Sarkar, Abhishek
Wang, Jeremy
Wang, Wei
Zhang, Qi

January 2011

The Collaborative Cross (CC) is a mouse recombinant inbred strain panel that is being developed as a...

Genetic Background Limits Generalizability of Genotype-Phenotype Relationships.

Sittig, Laura J
Carbonetto, Peter
Engel, Kyle A
Krauss, Kathleen S
Barrios-Camacho, Camila M
Palmer, Abraham A

September 2016

Genome-wide association studies (GWASs) have identified numerous loci that influence risk for psychi...

Association studies in outbred mice in a new era of full-genome sequencing

Yalcin, Binnaz
Flint, Jonathan

June 2018

Thousands of loci that contribute to quantitative traits in outbred crosses of mice have been report...

Genome-wide association of multiple complex traits in outbred mice by ultra low-coverage sequencing

Nicod, Jérôme
Davies, Robert W.
Cai, Na
Hassett, Carl
Goodstadt, Leo
Cosgrove, Cormac
Yee, Benjamin K.
Lionikaite, Vikte
McIntyre, Rebecca E.
Remme, Carol Ann
Lodder, Elisabeth M.
Gregory, Jennifer S.
Hough, Tertius
Joynson, Russell
Phelps, Hayley
Nell, Barbara
Rowe, Clare
Wood, Joe
Walling, Alison
Bopp, Nasrin
Bhomra, Amarjit
Hernandez-Pliego, Polinka
Callebert, Jacques
Aspden, Richard M.
Talbot, Nick P.
Robbins, Peter A.
Harrison, Mark
Fray, Martin
Launay, Jean-Marie
Pinto, Yigal M.
Blizard, David A.
Bezzina, Connie R.
Adams, David J.
Franken, Paul
Weaver, Tom
Wells, Sara
Brown, Steve D. M.
Potter, Paul K.
Klenerman, Paul
Lionikas, Arimantas
Mott, Richard
Flint, Jonathan

November 2016

The authors wish to acknowledge excellent technical assistance from A. Kurioka, L. Swadling, C. de L...

Assessing the prospects of genome-wide association studies performed in inbred mice.

Su, W L
Sieberts, S K
Kleinhanz, R R
Lux, K
Millstein, J
Molony, C
Schadt, E E

January 2010

The remarkable success in mapping genes linked to a number of disease traits using genome-wide assoc...

Genome wide association analysis in a mouse advanced intercross line.

Gonzales, Natalia M
Seo, Jungkyun
Hernandez Cordero, Ana I
St Pierre, Celine L
Gregory, Jennifer S
Distler, Margaret G
Abney, Mark
Canzar, Stefan
Lionikas, Arimantas
Palmer, Abraham A

December 2018

The LG/J x SM/J advanced intercross line of mice (LG x SM AIL) is a multigenerational outbred popula...

Genome-Wide Association Study in Two Cohorts from a Multi-generational Mouse Advanced Intercross Line Highlights the Difficulty of Replication Due to Study-Specific Heterogeneity

Xinzhu Zhou
Celine L. St. Pierre
Natalia M. Gonzales
Jennifer Zou
Riyan Cheng
Apurva S. Chitre
Greta Sokoloff
Abraham A. Palmer

March 2020

There has been extensive discussion of the “Replication Crisis” in many fields, including genome-wid...

Genome-Wide Association Study in Two Cohorts from a Multi-generational Mouse Advanced Intercross Line Highlights the Difficulty of Replication Due to Study-Specific Heterogeneity.

Zhou, Xinzhu
St Pierre, Celine L
Gonzales, Natalia M
Zou, Jennifer
Cheng, Riyan
Chitre, Apurva S
Sokoloff, Greta
Palmer, Abraham A

March 2020

There has been extensive discussion of the "Replication Crisis" in many fields, including genome-wid...

Genome-wide Association Discovery, Replication, and Validation in Mouse Models

Zhou, Xinzhu

January 2020

The “replication crisis” has highlighted the apparent lack of replication across scientific fields. ...

Genome wide association analysis in a mouse advanced intercross line

Gonzales, Natalia M.
Seo, Jungkyun
Cordero, Ana I. Hernandez
St Pierre, Celine L.
Gregory, Jennifer S.
Distler, Margaret G.
Abney, Mark
Canzar, Stefan
Lionikas, Arimantas
Palmer, Abraham A.

January 2018

The LG/J x SM/J advanced intercross line of mice (LG x SM AIL) is a multigenerational outbred popula...

Analysis of independent cohorts of outbred CFW mice reveals novel loci for behavioral and physiological traits and identifies factors determining reproducibility

Zou, J
Gopalakrishnan, S
Parker, CC
Nicod, J
Mott, R
Cai, N
Lionikas, A
Davies, RW
Palmer, AA
Flint, J

November 2021

Combining samples for genetic association is standard practice in human genetic analysis of complex ...

Genome-wide association studies and the problem of relatedness among advanced intercross lines and other highly recombinant populations

Cheng, Riyan
Lim, Jackie E
Samocha, Kaitlin E.
Sokoloff, Greta
Abney, Mark
Skol, Andrew D
Palmer, Abraham A

February 2016

Model organisms offer many advantages for the genetic analysis of complex traits. However, identific...

Genome-wide association studies in mice.

Flint, J
Eskin, E

January 2012

Genome-wide association studies (GWASs) have transformed the field of human genetics and have led to...

Genome-wide association of multiple complex traits in outbred mice by ultra-low-coverage sequencing

Nicod, J
Davies, RW
Cai, N
Hassett, C
Goodstadt, L
Cosgrove, C
Yee, BK
Lionikaite, V
McIntyre, RE
Remme, CA
Lodder, EM
Gregory, JS
Hough, T
Joynson, R
Phelps, H
Nell, B
Rowe, C
Wood, J
Walling, A
Bopp, N
Bhomra, A
Hernandez-Pliego, P
Callebert, J
Aspden, RM
Talbot, NP
Robbins, PA
Harrison, M
Fray, M
Launay, JM
Pinto, YM
Blizard, DA
Bezzina, CR
Adams, DJ
Franken, P
Weaver, T
Wells, S
Brown, SD
Potter, PK
Klenerman, P
Lionikas, A
Mott, R
Flint, J

August 2016

Two bottlenecks impeding the genetic analysis of complex traits in rodents are access to mapping pop...

Analysis of independent cohorts of outbred CFW mice reveals novel loci for behavioral and physiological traits and identifies factors determining reproducibility

Zou, Jennifer
Gopalakrishnan, Shyam
Parker, Clarissa
Nicod, Jerome
Mott, Richard
Cai, Na
Lionikas, Arimantas
Davies, Robert
Palmer, Abraham
Flint, Jonathan

October 2021

Combining samples for genetic association is standard practice in human genetic analysis of complex ...

Genetic analysis of complex traits in the emerging Collaborative Cross

Aylor, David L.
Valdar, William
Foulds-Mathes, Wendy
Buus, Ryan J.
Verdugo, Ricardo A.
Baric, Ralph S.
Ferris, Martin T.
Frelinger, Jeff A.
Heise, Mark
Frieman, Matt B.
Gralinski, Lisa E.
Bell, Timothy A.
Didion, John D.
Hua, Kunjie
Nehrenberg, Derrick L.
Powell, Christine L.
Steigerwalt, Jill
Xie, Yuying
Kelada, Samir N.P.
Collins, Francis S.
Yang, Ivana V.
Schwartz, David A.
Branstetter, Lisa A.
Chesler, Elissa J.
Miller, Darla R.
Spence, Jason
Liu, Eric Yi
McMillan, Leonard
Sarkar, Abhishek
Wang, Jeremy
Wang, Wei
Zhang, Qi

January 2011

The Collaborative Cross (CC) is a mouse recombinant inbred strain panel that is being developed as a...

Genetic Background Limits Generalizability of Genotype-Phenotype Relationships.

Sittig, Laura J
Carbonetto, Peter
Engel, Kyle A
Krauss, Kathleen S
Barrios-Camacho, Camila M
Palmer, Abraham A

September 2016

Genome-wide association studies (GWASs) have identified numerous loci that influence risk for psychi...

Association studies in outbred mice in a new era of full-genome sequencing

Yalcin, Binnaz
Flint, Jonathan

June 2018

Thousands of loci that contribute to quantitative traits in outbred crosses of mice have been report...

Genome-wide association of multiple complex traits in outbred mice by ultra low-coverage sequencing

Nicod, Jérôme
Davies, Robert W.
Cai, Na
Hassett, Carl
Goodstadt, Leo
Cosgrove, Cormac
Yee, Benjamin K.
Lionikaite, Vikte
McIntyre, Rebecca E.
Remme, Carol Ann
Lodder, Elisabeth M.
Gregory, Jennifer S.
Hough, Tertius
Joynson, Russell
Phelps, Hayley
Nell, Barbara
Rowe, Clare
Wood, Joe
Walling, Alison
Bopp, Nasrin
Bhomra, Amarjit
Hernandez-Pliego, Polinka
Callebert, Jacques
Aspden, Richard M.
Talbot, Nick P.
Robbins, Peter A.
Harrison, Mark
Fray, Martin
Launay, Jean-Marie
Pinto, Yigal M.
Blizard, David A.
Bezzina, Connie R.
Adams, David J.
Franken, Paul
Weaver, Tom
Wells, Sara
Brown, Steve D. M.
Potter, Paul K.
Klenerman, Paul
Lionikas, Arimantas
Mott, Richard
Flint, Jonathan

November 2016

The authors wish to acknowledge excellent technical assistance from A. Kurioka, L. Swadling, C. de L...

Assessing the prospects of genome-wide association studies performed in inbred mice.

Su, W L
Sieberts, S K
Kleinhanz, R R
Lux, K
Millstein, J
Molony, C
Schadt, E E

January 2010

The remarkable success in mapping genes linked to a number of disease traits using genome-wide assoc...

Genome wide association analysis in a mouse advanced intercross line.

Gonzales, Natalia M
Seo, Jungkyun
Hernandez Cordero, Ana I
St Pierre, Celine L
Gregory, Jennifer S
Distler, Margaret G
Abney, Mark
Canzar, Stefan
Lionikas, Arimantas
Palmer, Abraham A

December 2018

The LG/J x SM/J advanced intercross line of mice (LG x SM AIL) is a multigenerational outbred popula...

Genome-wide association study in two cohorts from a multi-generational mouse advanced intercross line highlights the difficulty of replication due to study-specific heterogeneity

Abstract

Extracted data

Genome-wide association study in two cohorts from a multi-generational mouse advanced intercross line highlights the difficulty of replication due to study-specific heterogeneity

Abstract

Extracted data

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