Paradoxical role of CD16+CCR2+CCR5+ monocytes in tuberculosis: efficient APC in pleural effusion but also mark disease severity in blood
- Balboa, Luciana
- Romero, María Mercedes
- Basile, Juan Ignacio
- Sabio y García, Carmen Alejandra
- Schierloh, Luis Pablo
- Yokobori, Noemí
- Geffner, Laura Judith
- Musella, Rosa María
- Castagnino, Jorge
- Abbate, Eduardo
- de la Barrera, Silvia Susana
- Sasiain, María del Carmen
- Alemán, Mercedes
DOIAbstract
The role of CD16- and CD16+ Mo subsets in human TB remains unknown. Our aim was to characterize Mo subsets from TB patients and to assess whether the inflammatory milieu from TB pleurisy modulate their phenotype and recruitment. We found an expansion of peripheral CD16+ Mo that correlated with disease severity and with TNF-α plasma levels. Circulating Mo from TB patients are activated, showing a higher CD14, CD16, and CD11b expression and Mtb binding than HS. Both subsets coexpressed CCR2/CCR5, showing a potential ability to migrate to the inflammatory site. In tuberculous PF, the CD16+ subset was the main Mo/MΦ population, accumulation that can be favored by the induction of CD16 expression in CD16? Mo triggered by soluble factors found in...
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