Methylation status regulates LPL expression in Chronic Lymphocytic Leukemia
- Abreu, Cecilia
- Moreno, Pilar
- Palacios, Florencia
- Borge, Mercedes
- Morande, Pablo Elías
- Landoni, Ana Ines
- Gabus, Raul
- Dighiero, Guillermo
- Giordano, Mirta Nilda
- Gamberale, Romina
- Oppezzo, Pablo
DOIAbstract
Among different prognostic factors in chronic lymphocytic leukemia (CLL), we previously demonstrated that lipoprotein lipase (LPL) is associated with an unmutated immunoglobulin profile and clinical poor outcome. Despite the usefulness of LPL for CLL prognosis, its functional role and the molecular mechanism regulating its expression are still open questions. Interaction of CLL B-cells with the tissue microenvironment favors disease progression by promoting malignant B-cell growth. Since tissue methylation can be altered by environmental factors, we investigated the methylation status of the LPL gene and the possibility that overexpression could be associated with microenvironment signals. Our results show that a demethylated state of the L...
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