Oxfendazole kinetics in pigs: In vivo assessment of its pattern of accumulation in Ascaris suum
- Ceballos, Laura
- Cantón, Candela
- Cadenazzi, Gabriela Esther
- Virkel, Guillermo Leon
- Dominguez, Maria Paula
- Moreno Torrejon, Laura
- Lanusse, Carlos Edmundo
- Alvarez, Luis Ignacio
DOIAbstract
Ascaris suum is a widespread parasitic nematode that causes infection in pigs with high prevalence rates. Oxfendazole (OFZ) is effective against A. suum when used at a single high oral dose of 30 mg/kg. The aim of this study was to assess the pattern of distribution/accumulation of OFZ and its metabolites, in bloodstream (plasma), mucosal tissue and contents from small and large intestine and adult specimens of A. suum collected from infected and treated pigs. The activity of glutathione-S-transferases (GSTs) in A. suum was also investigated. Infected pigs were orally treated with OFZ (30 mg/kg) and sacrificed at 0, 3, 6 and 12 h after treatment. Samples of blood, mucosa and contents from both small and large intestine as well as adult worm...
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