Is Lactoferrin More Effective in Reducing Late-Onset Sepsis in Preterm Neonates Fed Formula Than in Those Receiving Mother's Own Milk? Secondary Analyses of Two Multicenter Randomized Controlled Trials
- Manzoni P.
- Militello M. A.
- Rizzollo S.
- Tavella E.
- Messina A.
- Pieretto M.
- Boano E.
- Carlino M.
- Tognato E.
- Spola R.
- Perona A.
- Maule M. M.
- Garcia Sanchez R.
- Meyer M.
- Stolfi I.
- Pugni L.
- Messner H.
- Cattani S.
- Betta P. M.
- Memo L.
- Decembrino L.
- Bollani L.
- Rinaldi M.
- Fioretti M.
- Quercia M.
- Tzialla C.
- Laforgia N.
- Mosca F.
- Magaldi R.
- Mostert M.
- Farina D.
- Tarnow-Mordi W.
DOIAbstract
Background: Lactoferrin is the major antimicrobial protein in human milk. In our randomized controlled trial (RCT) of bovine lactoferrin (BLF) supplementation in preterm neonates, BLF reduced late-onset sepsis (LOS). Mother's own milk (MM) contains higher concentrations of lactoferrin than donor milk or formula, but whether BLF is more effective in infants who receive formula or donor milk is uncertain. Aim: To evaluate the incidence of LOS in preterm infants fed MM and in those fed formula and/or donor milk. Study Design: This is a (A) post hoc subgroup analysis, in our RCT of BLF, of its effects in preterm infants fed MM, with or without formula, versus those fed formula and/or donor milk (no-MM) and (B) post hoc meta-analysis, in our RCT...
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