Mycobacterial and human nitrobindins: structure and function
- De Simone, Giovanna
- di Masi, Alessandra
- Vita, Gian Marco
- Polticelli, Fabio
- Pesce, Alessandra
- Nardini, Marco
- Bolognesi, Martino
- Ciaccio, Chiara
- Coletta, Massimiliano
- Turilli, Emily Samuela
- Fasano, Mauro
- Tognaccini, Lorenzo
- Smulevich, Giulietta
- Abbruzzetti, Stefania
- Viappiani, Cristiano
- Bruno, Stefano
- Ascenzi, Paolo
Publication date
January 2020
DOIAbstract
Nitrobindins (Nbs) are evolutionary conserved all-β-barrel heme-proteins displaying a highly solvent-exposed heme-Fe(III) atom. The physiological role(s) of Nbs is almost unknown. Here, the structural and functional properties of the Mycobacterium tuberculosis Nb (Mt-Nb(III)) and Homo sapiens Nb (Hs-Nb(III)) have been investigated and compared with those of Arabidopsis thaliana Nb (At-Nb(III), of the hematophagous bug Rodius prolixus nitrophorins (Rp-NP(III)s), and of mammalian myoglobins
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