Add to ORKGTo identify loci affecting the electrocardiographic QT interval, a measure of cardiac repolarisation associated with risk of ventricular arrhythmias and sudden cardiac death, we conducted a meta-analysis of three genome-wide association studies (GWAS) including 3,558 subjects from the TwinsUK and BRIGHT cohorts in the UK and the DCCT/EDIC cohort from North America. Five loci were significantly associated with QT interval at P<1×10−6. To validate these findings we performed an in silico comparison with data from two QT consortia: QTSCD (n = 15,842) and QTGEN (n = 13,685). Analysis confirmed the association between common variants near NOS1AP (P = 1.4×10−83) and the phospholamban (PLN) gene (P = 1.9×10−29). The most associated SNP near NOS1AP...
To identify loci affecting the electrocardiographic QT interval, a measure of cardiac repolarisation...
To access publisher's full text version of this article click on the hyperlink at the bottom of the ...
The QT interval, an electrocardiographic measure reflecting myocardial repolarization, is a heritabl...
To identify loci affecting the electrocardiographic QT interval, a measure of cardiac repolarisation...
To identify loci affecting the electrocardiographic QT interval, a measure of cardiac repolarisation...
To identify loci affecting the electrocardiographic QT interval, a measure of cardiac repolarisation...
To identify loci affecting the electrocardiographic QT interval, a measure of cardiac repolarisation...
To identify loci affecting the electrocardiographic QT interval, a measure of cardiac repolarisation...
To identify loci affecting the electrocardiographic QT interval, a measure of cardiac repolarisation...
To identify loci affecting the electrocardiographic QT interval, a measure of cardiac repolarisation...
To access publisher's full text version of this article click on the hyperlink at the bottom of the ...
The QT interval, an electrocardiographic measure reflecting myocardial repolarization, is a heritabl...
To identify loci affecting the electrocardiographic QT interval, a measure of cardiac repolarisation...
To identify loci affecting the electrocardiographic QT interval, a measure of cardiac repolarisation...
To identify loci affecting the electrocardiographic QT interval, a measure of cardiac repolarisation...
To identify loci affecting the electrocardiographic QT interval, a measure of cardiac repolarisation...
To identify loci affecting the electrocardiographic QT interval, a measure of cardiac repolarisation...
To identify loci affecting the electrocardiographic QT interval, a measure of cardiac repolarisation...
To identify loci affecting the electrocardiographic QT interval, a measure of cardiac repolarisation...
To access publisher's full text version of this article click on the hyperlink at the bottom of the ...
The QT interval, an electrocardiographic measure reflecting myocardial repolarization, is a heritabl...