The primary cilium, once considered an evolutionary vestige, has re-emerged as an essential organelle for the normal functioning of a wide variety of cellular processes. It is now clear that it has important roles in the control of cell proliferation and signalling during development, with defects in primary cilia being a major cause of many human diseases. These disorders, collectively referred to as ciliopathies, include the cystic kidney diseases that are characterized by aberrant cell proliferation and cyst formation. Mutations in the NIMA-related kinase, Nek8, are associated with cystic kidney disease in both humans and mice, with Nek8 being the candidate NPHP9 gene in the human juvenile cystic kidney disease, nephronophthisis. Previou...
International audienceCiliopathies are a group of genetic multi-systemic disorders related to dysfun...
International audienceCiliopathies are a group of genetic multi-systemic disorders related to dysfun...
International audienceCiliopathies are a group of genetic multi-systemic disorders related to dysfun...
The primary cilium, once considered an evolutionary vestige, has re-emerged as an essential organell...
Ciliopathies, which are caused by defects in cilia and basal bodies include the cystic kidney diseas...
Background: Mutations in Nek1 (NIMA-Related Kinase 1) are causal in the murine models ofpolycystic k...
Abstract Background Mutations in Nek1 (NIMA-Related Kinase 1) are causal in the murine models of pol...
Nek9, Nek6, and Nek7, are NIMA-related protein kinases (Neks) with different functions during the ce...
AbstractRecent studies implicate primary cilium (PC) proteins in the etiologies of various polycysti...
The NIMA-related kinases are the least well characterised of the so-called cell cycle kinases. Mount...
Nek8 is a serine/threonine kinase that is mutated in the jck (juvenile cystic kidneys) mouse, a mode...
Mutations affecting the integrity and function of cilia have been identified in various genes over t...
Nek1 is a member of NIMA related kinases in mammals that has been known to regulate ciliogenesis. Lo...
International audienceCiliopathies are a group of genetic multi-systemic disorders related to dysfun...
International audienceCiliopathies are a group of genetic multi-systemic disorders related to dysfun...
International audienceCiliopathies are a group of genetic multi-systemic disorders related to dysfun...
International audienceCiliopathies are a group of genetic multi-systemic disorders related to dysfun...
International audienceCiliopathies are a group of genetic multi-systemic disorders related to dysfun...
The primary cilium, once considered an evolutionary vestige, has re-emerged as an essential organell...
Ciliopathies, which are caused by defects in cilia and basal bodies include the cystic kidney diseas...
Background: Mutations in Nek1 (NIMA-Related Kinase 1) are causal in the murine models ofpolycystic k...
Abstract Background Mutations in Nek1 (NIMA-Related Kinase 1) are causal in the murine models of pol...
Nek9, Nek6, and Nek7, are NIMA-related protein kinases (Neks) with different functions during the ce...
AbstractRecent studies implicate primary cilium (PC) proteins in the etiologies of various polycysti...
The NIMA-related kinases are the least well characterised of the so-called cell cycle kinases. Mount...
Nek8 is a serine/threonine kinase that is mutated in the jck (juvenile cystic kidneys) mouse, a mode...
Mutations affecting the integrity and function of cilia have been identified in various genes over t...
Nek1 is a member of NIMA related kinases in mammals that has been known to regulate ciliogenesis. Lo...
International audienceCiliopathies are a group of genetic multi-systemic disorders related to dysfun...
International audienceCiliopathies are a group of genetic multi-systemic disorders related to dysfun...
International audienceCiliopathies are a group of genetic multi-systemic disorders related to dysfun...
International audienceCiliopathies are a group of genetic multi-systemic disorders related to dysfun...
International audienceCiliopathies are a group of genetic multi-systemic disorders related to dysfun...