Huntington’s disease (HD) is a fatal late onset neurodegenerative disorder that is caused by an expansion of a polyglutamine encoding tract in the Huntingtin gene. This expansion in mutant huntingtin (mHtt) causes the protein to misfold, aggregate and leads to widespread cellular dysfunction principally through a toxic gain of function mechanism. The expression of mHtt in baker’s yeast recapitulates many of the cellular phenotypes observed in mammalian models. Here I have exploited a yeast HD model to perform genetic screens for mammalian cDNAs whose overexpression suppresses mHtt toxicity. We identified 102 protective genes, which are significantly enriched for components of the translational machinery. Further investigations revealed tha...
<div><h3>Background</h3><p>Polyglutamine expansion is responsible for several neurodegenerative diso...
Polyglutamine-expanded fragments, derived from the human huntingtin protein, are aggregation-prone a...
Neurodegenerative diseases (NDs) present major health and economic challenges to modern societies. N...
Huntington’s disease (HD) is a fatal late onset neurodegenerative disorder that is caused by an expa...
Huntington disease (HD) is a neurodegenerative disorder caused by the expansion of a polyglutamine t...
Huntington’s disease (HD) is a fatal neurodegenerative disorder caused by a polyglutamine expansion ...
Expansions of preexisting polyglutamine (polyQ) tracts in at least nine different proteins cause dev...
Huntington's disease (HD) is a fatal neurodegenerative disorder caused by a polyglutamine expansion ...
Huntington\u27s disease is caused by the pathological expansion of a polyglutamine (polyQ) stretch i...
Huntington’s disease (HD) and Parkinson’s disease (PD) are neurodegenerative diseases (NDs) in which...
Huntington's disease (HD) is a fatal genetic neurodegenerative disorder caused by a CAG repeat expan...
BACKGROUND: Polyglutamine expansion is responsible for several neurodegenerative disorders, among wh...
BACKGROUND: Huntingtons disease (HD) is a genetic neurodegenerative disease caused by trinucleotide ...
Many neurodegenerative disorders display protein aggregation as a hallmark, Huntingtin and TDP-43 ag...
<div><p>In polyglutamine (polyQ) diseases including Huntington's disease (HD), mutant proteins conta...
<div><h3>Background</h3><p>Polyglutamine expansion is responsible for several neurodegenerative diso...
Polyglutamine-expanded fragments, derived from the human huntingtin protein, are aggregation-prone a...
Neurodegenerative diseases (NDs) present major health and economic challenges to modern societies. N...
Huntington’s disease (HD) is a fatal late onset neurodegenerative disorder that is caused by an expa...
Huntington disease (HD) is a neurodegenerative disorder caused by the expansion of a polyglutamine t...
Huntington’s disease (HD) is a fatal neurodegenerative disorder caused by a polyglutamine expansion ...
Expansions of preexisting polyglutamine (polyQ) tracts in at least nine different proteins cause dev...
Huntington's disease (HD) is a fatal neurodegenerative disorder caused by a polyglutamine expansion ...
Huntington\u27s disease is caused by the pathological expansion of a polyglutamine (polyQ) stretch i...
Huntington’s disease (HD) and Parkinson’s disease (PD) are neurodegenerative diseases (NDs) in which...
Huntington's disease (HD) is a fatal genetic neurodegenerative disorder caused by a CAG repeat expan...
BACKGROUND: Polyglutamine expansion is responsible for several neurodegenerative disorders, among wh...
BACKGROUND: Huntingtons disease (HD) is a genetic neurodegenerative disease caused by trinucleotide ...
Many neurodegenerative disorders display protein aggregation as a hallmark, Huntingtin and TDP-43 ag...
<div><p>In polyglutamine (polyQ) diseases including Huntington's disease (HD), mutant proteins conta...
<div><h3>Background</h3><p>Polyglutamine expansion is responsible for several neurodegenerative diso...
Polyglutamine-expanded fragments, derived from the human huntingtin protein, are aggregation-prone a...
Neurodegenerative diseases (NDs) present major health and economic challenges to modern societies. N...