Besides altering its own expression during cell transformation, Annexin A2 is upregulated during the progression of many cancer types and also plays key roles during viral infection and multiplication. Consequently, there has been great interest in Annexin A2 as a potential drug target. The successful design of efficient in vivo delivery systems constitutes an obstacle in full exploitation of antisense and RNA-cleaving technologies for the knock-down of specific targets. Efficiency is dependent on the method of delivery and accessibility of the target. Here, hairpin ribozymes and an antisense RNA against rat annexin A2 mRNA were tested for their efficiencies in a T7-driven coupled transcription/translation system. The most efficient ribozym...
International audienceAnnexins are widely distributed and have been described in lung as well as in ...
Hammerhead and hairpin ribozymes are short RNAs that act as sequence-specific endoribonucleases by c...
[[abstract]]Ribozymes have been developed to cleave the ber-abl transcripts and thereby suppress tra...
Besides altering its own expression during cell transformation, Annexin A2 is upregulated during the...
<p>A2 = Annexin A2; Mock = control group, only empty plasmid transfected; NC = Negative control grou...
Annexin A2 (ANXA2) is a protein implicated in diverse cellular functions, including exocytosis, DNA ...
AbstractObjectiveTo study the effects of inhibited Annexin A2 (ANXA2) on human umbilical vein endoth...
<p>(A) TIME ANXA2 shRNA1, TIME ANXA2 shRNA2 or TIME ANXA2 scramble cells were treated with 10 Gy IR ...
Annexin A2 is an abundant cellular protein that is mainly localized in the cytoplasm and plasma memb...
AIDS is caused by a lentivirus, HIV-1. In addition to antiretroviral drugs that are currently in use...
The tight regulation of protein expression is critical for the survival of mammalian cells, providin...
International audienceRNA interference (RNAi) is a potent cellular system against viruses in various...
retroelement DIRS-1 is suppressed by RNAi mechanisms. Here we provide evidence that both inverted t...
Short hairpin RNAs (shRNAs)can induce gene silencing via the RNA interference (RNAi)mechanism. We de...
International audienceBACKGROUND: Deliberate cellular reprogramming is becoming a realistic objectiv...
International audienceAnnexins are widely distributed and have been described in lung as well as in ...
Hammerhead and hairpin ribozymes are short RNAs that act as sequence-specific endoribonucleases by c...
[[abstract]]Ribozymes have been developed to cleave the ber-abl transcripts and thereby suppress tra...
Besides altering its own expression during cell transformation, Annexin A2 is upregulated during the...
<p>A2 = Annexin A2; Mock = control group, only empty plasmid transfected; NC = Negative control grou...
Annexin A2 (ANXA2) is a protein implicated in diverse cellular functions, including exocytosis, DNA ...
AbstractObjectiveTo study the effects of inhibited Annexin A2 (ANXA2) on human umbilical vein endoth...
<p>(A) TIME ANXA2 shRNA1, TIME ANXA2 shRNA2 or TIME ANXA2 scramble cells were treated with 10 Gy IR ...
Annexin A2 is an abundant cellular protein that is mainly localized in the cytoplasm and plasma memb...
AIDS is caused by a lentivirus, HIV-1. In addition to antiretroviral drugs that are currently in use...
The tight regulation of protein expression is critical for the survival of mammalian cells, providin...
International audienceRNA interference (RNAi) is a potent cellular system against viruses in various...
retroelement DIRS-1 is suppressed by RNAi mechanisms. Here we provide evidence that both inverted t...
Short hairpin RNAs (shRNAs)can induce gene silencing via the RNA interference (RNAi)mechanism. We de...
International audienceBACKGROUND: Deliberate cellular reprogramming is becoming a realistic objectiv...
International audienceAnnexins are widely distributed and have been described in lung as well as in ...
Hammerhead and hairpin ribozymes are short RNAs that act as sequence-specific endoribonucleases by c...
[[abstract]]Ribozymes have been developed to cleave the ber-abl transcripts and thereby suppress tra...