1. Glucocorticoids are an effective treatment in the amelioration of chronic lung disease in neonates. However, systemic administration of glucocorticoids to neonates is associated with significant side-effects that preclude them as an early intervention to prevent onset of the condition. Conversely, local intratracheal administration of glucocorticoids may prevent inflammatory insult to the lungs without the development of systemic side-effects. We therefore investigated whether local intratracheal delivery of corticosteroids could be facilitated using surfactant as a vehicle.\ud \ud 2. Addition of dexamethasone to either diluted or commercial artificial surfactant, Survanta (Abbott Industries, Sydney, NSW, Australia), did not alter the su...
textabstractThe neonatal respiratory distress syndrome (RDS) is characterized by immaturity of the l...
Bronchopulmonary dysplasia (BPD) is the most significant respiratory complication of prematurity, an...
As an organ system, the lung has unique advantages and disadvantages for direct drug delivery. Its c...
1. Glucocorticoids are an effective treatment in the amelioration of chronic lung disease in neonate...
BackgroundChronic lung disease continues to be a major complication in premature infants with severe...
Concern about adverse outcomes with the use of systemic postnatal corticosteroids (PCS) for bronchop...
Although there is supporting evidence that glucocorticoids improve the short-term pulmonary outcome ...
Intratracheal administration of corticosteroids using a natural pulmonary surfactant as a delivery v...
Rationale: Bronchopulmonary dysplasia (BPD) is an important complication of mechanical ventilation i...
Over the last 10 years the strategy for the prevention of neonatal respiratory distress syndrome (RD...
Pulmonary surfactant is a crucial system to stabilize the respiratory air–liquid interface. Furtherm...
Pulmonary surfactant is a crucial system to stabilize the respiratory air-liquid interface. Furtherm...
BackgroundThe intratracheal (IT) administration of budesonide using surfactant as a vehicle has been...
Recent clinical trials in newborns have successfully used surfactant as a drug carrier for an active...
Lung inflammation in premature infants contributes to the development of bronchopulmonary dysplasia ...
textabstractThe neonatal respiratory distress syndrome (RDS) is characterized by immaturity of the l...
Bronchopulmonary dysplasia (BPD) is the most significant respiratory complication of prematurity, an...
As an organ system, the lung has unique advantages and disadvantages for direct drug delivery. Its c...
1. Glucocorticoids are an effective treatment in the amelioration of chronic lung disease in neonate...
BackgroundChronic lung disease continues to be a major complication in premature infants with severe...
Concern about adverse outcomes with the use of systemic postnatal corticosteroids (PCS) for bronchop...
Although there is supporting evidence that glucocorticoids improve the short-term pulmonary outcome ...
Intratracheal administration of corticosteroids using a natural pulmonary surfactant as a delivery v...
Rationale: Bronchopulmonary dysplasia (BPD) is an important complication of mechanical ventilation i...
Over the last 10 years the strategy for the prevention of neonatal respiratory distress syndrome (RD...
Pulmonary surfactant is a crucial system to stabilize the respiratory air–liquid interface. Furtherm...
Pulmonary surfactant is a crucial system to stabilize the respiratory air-liquid interface. Furtherm...
BackgroundThe intratracheal (IT) administration of budesonide using surfactant as a vehicle has been...
Recent clinical trials in newborns have successfully used surfactant as a drug carrier for an active...
Lung inflammation in premature infants contributes to the development of bronchopulmonary dysplasia ...
textabstractThe neonatal respiratory distress syndrome (RDS) is characterized by immaturity of the l...
Bronchopulmonary dysplasia (BPD) is the most significant respiratory complication of prematurity, an...
As an organ system, the lung has unique advantages and disadvantages for direct drug delivery. Its c...