Abstract 177: Rat to pig translation: small-volume 7.5% NaCl adenocaine/Mg2+ has multiple physiological benefits during hypotensive and blood resuscitation in the porcine model of severe hemorrhagic shock \ud

[Extract] Background: Currently there is no effective small-volume fluid for hypotensive resuscitation in far-forward combat environments. In the rat model of extreme hemorrhagic shock, we have shown that a small IV bolus of 7.5% NaCl Adenocaine (adenosine and lidocaine) and Mg2+ (ALM) had a significant hemodynamic and survival benefit. The present study tests whether small-volume 7.5% NaCl ALM translates from rat to the porcine model of severe hemorrhagic shock.\ud \ud Methods: Pigs (35-40kg) were anesthetized and bled to mean arterial pressure (MAP) of 35-40 mmHg for 90 min (~75% blood loss). Pigs were randomly assigned to receive 4 ml/kg 7.5% NaCl (n=8) or 4 ml/kg 7.5% NaCl ALM (n=8). Data were collected at baseline, shock, hypotensive fluid resuscitation (60 min), and during return of shed blood (180 min). Core temperature (CT) was 38.2°C and allowed to drift during shock and resuscitation. Sig*p