Implementation and validation of ASL perfusion measurements for population imaging

Warnert, E.A.H. (Esther A. H.)
Steketee, R.M.E. (Rebecca)
Vernooij, M.W. (Meike)
Ikram, M.A. (Arfan)
Vogel, M.W. (Mika)
Hernandez Tamames, J.-A. (Juan-Antonio)
Kotek, G. (Gyula)

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Publication date

April 2020

DOI

10.1002/mrm.28271

Publisher

Wiley

Language

English

Abstract

Purpose: Pseudocontinuous arterial spin labeling (pCASL) allows for noninvasive measurement of regional cerebral blood flow (CBF), which has the potential to serve as biomarker for neurodegenerative and cardiovascular diseases. This work aimed to implement and validate pCASL on the dedicated MRI system within the population-based Rotterdam Study, which was installed in 2005 and for which software and hardware configurations have remained fixed. Methods: Imaging was performed on two 1.5T MRI systems (General Electric); (I) the Rotterdam Study system, and (II) a hospital-based system with a product pCASL sequence. An in-house implementation of pCASL was created on scanner I. A flow phantom and three healthy volunteers (<27 years) were scanned...