Amyloidosis

• Pathogenesis: abnormal proteinaceous deposits accumulate within tissues.\ud \ud • Signs: depend on which tissues are disrupted by amyloid accumulation.\ud \ud • May be systemic or localized: kidneys often affected, also liver and spleen.\ud \ud • Treatment: few options: colchicine and dimethyl sulfoxide (DMSO) have been tried.\ud \ud • Prognosis: usually progressive until death.\ud \ud • Familial and sporadic forms also occur.\u