Systemic antibodies administered by passive immunization prevent generalization of the infection by foot-and-mouth disease virus in cattle after oronasal challenge
- Barrionuevo, Florencia Mariel
- Di Giacomo, Sebastián
- Bucafusco, Danilo
- Ayude, Andrea Fabiana
- Schammas, Juan Manuel
- Miraglia, María Cruz
- Capozzo, Alejandra Victoria
- Borca, Manuel Victor
- Perez Filgueira, Daniel Mariano
DOIAbstract
The role of passively transferred sera in the protection against aerogenous foot-and-mouth disease (FMD) virus infection in cattle was evaluated using vaccine-induced immune serum preparations obtained at 7 and 26 days post-vaccination (dpv). We showed that circulating antibodies were sufficient to prevent disease generalization after oronasal infection in animals passively transferred with 26-dpv serum but not with the 7-dpv serum. Conversely, conventional FMD vaccination provided clinical protection at 7 dpv, promoting fast and robust antibody responses upon challenge and even though antibody titers were similar to those found in animals passively immunized with 7-dpv serum. These results demonstrate that presence of antigen-specific anti...
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