The hydrodynamic interaction between two particles, suspended in shear flows, is fundamental to the macroscopic characterization of suspension flows. Although the understanding of the hydrodynamic interaction between two particles suspended in a quiescent or linear shear flow is mature, studies of the interaction in a non-linear shear field are rare. The current study calculates such\ud interactions between two neutrally-buoyant smooth spheres moving at negligible Reynolds numbers in an unbounded wide-gap Couette flow by three-dimensional boundary-element method (BEM) simulations. Both the identical sphere-pair and the disparate sphere-pair are considered. The numerical\ud results show that there is a preferential cross-streamline migration...