BACKGROUND: Obesity, hypertension and prediabetes contribute greatly to coronary artery disease, heart failure and vascular events, and are the leading cause of mortality and morbidity in developed societies. Salt sensitivity exacerbates endothelial dysfunction. Herein, we investigated the effect of chronic glucagon like peptide-1 (GLP-1) receptor activation on the coronary microcirculation and cardiac remodeling in Zucker rats on a high-salt diet (6% NaCl). METHODS: Eight-week old Zucker lean (+/+) and obese (fa/fa) rats were treated with vehicle or liraglutide (LIRA) (0.1 mg/kg/day, s.c.) for 8 weeks. Systolic blood pressure (SBP) was measured using tail-cuff method in conscious rats. Myocardial function was assessed by echocardiography. ...
Background: Lixisenatide is a glucagon-like peptide-1 analog which stimulates insulin secretion and ...
ObjectiveThe efficacy of liraglutide, a human glucagon-like peptide-1 (GLP-1) analog, to prevent or ...
OBJECTIVE—Glucagon-like peptide-1 receptor (GLP-1R) ago-nists are used to treat type 2 diabetes, and...
BACKGROUND: Diabetes mellitus (DM) induces cardiac and cerebral microvascular dysfunction via increa...
Abstract Background We investigated the effects of liraglutide on the formation and progression of a...
Polycystic ovarian syndrome (PCOS) is the most common endocrine disorder in women of reproductive ag...
Aim. This study aimed to investigate whether the glucagon-like peptide-1 analog liraglutide (LIRA) c...
A high salt intake exacerbates insulin resistance, evoking hypertension due to systemic perivascular...
Copyright © 2013 Jieyu Liu et al.This is an open access article distributed under the Creative Commo...
Polycystic ovarian syndrome (PCOS) is the most common endocrine disorder in women of reproductive ag...
This study tested the hypothesis that glucagon-like peptide 1 (GLP-1) therapies improve cardiac cont...
Metabolic syndrome is associated with pathologies that include type 2 diabetes, hypertension, and dy...
Vascular endothelial insulin signaling is critical for the maintenance of vascular and metabolic hom...
Right ventricular (RV) function is the major determinant of prognosis in pulmonary hypertension (PH)...
BACKGROUND: Glucagon-like peptide-1 (GLP-1) treatment leads to short-term improvements in myocardial...
Background: Lixisenatide is a glucagon-like peptide-1 analog which stimulates insulin secretion and ...
ObjectiveThe efficacy of liraglutide, a human glucagon-like peptide-1 (GLP-1) analog, to prevent or ...
OBJECTIVE—Glucagon-like peptide-1 receptor (GLP-1R) ago-nists are used to treat type 2 diabetes, and...
BACKGROUND: Diabetes mellitus (DM) induces cardiac and cerebral microvascular dysfunction via increa...
Abstract Background We investigated the effects of liraglutide on the formation and progression of a...
Polycystic ovarian syndrome (PCOS) is the most common endocrine disorder in women of reproductive ag...
Aim. This study aimed to investigate whether the glucagon-like peptide-1 analog liraglutide (LIRA) c...
A high salt intake exacerbates insulin resistance, evoking hypertension due to systemic perivascular...
Copyright © 2013 Jieyu Liu et al.This is an open access article distributed under the Creative Commo...
Polycystic ovarian syndrome (PCOS) is the most common endocrine disorder in women of reproductive ag...
This study tested the hypothesis that glucagon-like peptide 1 (GLP-1) therapies improve cardiac cont...
Metabolic syndrome is associated with pathologies that include type 2 diabetes, hypertension, and dy...
Vascular endothelial insulin signaling is critical for the maintenance of vascular and metabolic hom...
Right ventricular (RV) function is the major determinant of prognosis in pulmonary hypertension (PH)...
BACKGROUND: Glucagon-like peptide-1 (GLP-1) treatment leads to short-term improvements in myocardial...
Background: Lixisenatide is a glucagon-like peptide-1 analog which stimulates insulin secretion and ...
ObjectiveThe efficacy of liraglutide, a human glucagon-like peptide-1 (GLP-1) analog, to prevent or ...
OBJECTIVE—Glucagon-like peptide-1 receptor (GLP-1R) ago-nists are used to treat type 2 diabetes, and...