CD51/CD61+ Endothelial Microparticles Decrease in Diabetes Patients with Hypertension

Backgrounds: Type 2 Diabetes Mellitus (T2DM) and hypertension are commonly co-occurred and both diseases are related to endothelial dysfunction. Endothelial microparticles (EMPs) are shed from endothelial cells and can be found in condition of endothelial dysfunction. This study aimed to evaluate the circulating endothelial MPs (CD51/CD61+) levels in T2DM patients with or without hypertension and the correlation between endothelial MPs and clinical parameters. Methods and Results: 20 healthy control, 16 T2DM patients without hypertension and 11 T2DM patients with hypertension were recruited. CD51/CD61+ EMPs from all subjects were analyzed by flow cytometry. We found that, in the group of T2DM patients with hypertension, the absolute median number of CD51/CD61+EMPs was significantly decreased, compared with that in the healthy control and T2DM without hypertension groups. Furthermore, we conducted receiver operating characteristics (ROC) analysis to examine the accuracy of CD51/CD61+EMPs in the discrimination  between T2DM patients with hypertension and healthy control, showing the accuracy was 76.4%. In addition, we also found that the accuracy of CD51/CD61+EMPs was 83.5% in the discrimination between T2DM patients with hypertension or without hypertension Conclusion: These findings identify CD51/CD61+EMPs as a potential biomarker to monitor endothelial dysfunction in T2DM patients with hypertension