Add to ORKGTransforming growth factor beta (TGFβ) is a multipotent immunosuppressive cytokine. TGFβ excludes immune cells from tumors, and TGFβ inhibition improves the efficacy of cytotoxic and immune therapies. Using preclinical colorectal cancer models in cell type-conditional TGFβ receptor I (ALK5) knockout mice, we interrogate this mechanism. Tumor growth delay and radiation response are unchanged in animals with Treg or macrophage-specific ALK5 deletion. However, CD8αCre-ALK
AbstractThe type III TGF-β receptor (TβRIII or betagylcan) is a TGF-β superfamily coreceptor with em...
The type III TGF-β receptor (TβRIII or betagylcan) is a TGF-β superfamily coreceptor with emerging r...
Transforming growth factor-beta1 (TGF-β) regulates a plethora of cell-intrinsic processes that modul...
Transforming growth factor beta (TGFβ) is a multipotent immunosuppressive cytokine. TGFβ excludes im...
Alterations of TGF-β signaling have been described in colorectal cancer, although the molecular cons...
Transforming Growth Factor beta (TGF-β) is a pleiotropic cytokine produced in large amounts within c...
Most patients with colorectal cancer die as a result of the disease spreading to other organs. Howev...
Novel immune therapeutic tools are rapidly expanding the anticancer arsenal. Despite this progress, ...
TGFβ is a pleiotropic cytokine that plays critical roles to define cancer cell phenotypes, construct...
International audienceBackground Transforming growth factor-beta (TGFβ) can limit the efficacy of ca...
TGFβ signaling is associated with non-response to immune checkpoint blockade in patients with advanc...
Recent investigations support an important role for TGF-β in the development of colorectal cancer. H...
The transforming growth factor β (TGFβ) signaling pathway is a key player in metazoan biology, and i...
TGF-β is a pleiotropic cytokine with powerful immunosuppressive functions. Mice deficient for TGF-β1...
Previous studies have suggested that TGF-β functions as a tumor promoter in metastatic, mesenchymal-...
AbstractThe type III TGF-β receptor (TβRIII or betagylcan) is a TGF-β superfamily coreceptor with em...
The type III TGF-β receptor (TβRIII or betagylcan) is a TGF-β superfamily coreceptor with emerging r...
Transforming growth factor-beta1 (TGF-β) regulates a plethora of cell-intrinsic processes that modul...
Transforming growth factor beta (TGFβ) is a multipotent immunosuppressive cytokine. TGFβ excludes im...
Alterations of TGF-β signaling have been described in colorectal cancer, although the molecular cons...
Transforming Growth Factor beta (TGF-β) is a pleiotropic cytokine produced in large amounts within c...
Most patients with colorectal cancer die as a result of the disease spreading to other organs. Howev...
Novel immune therapeutic tools are rapidly expanding the anticancer arsenal. Despite this progress, ...
TGFβ is a pleiotropic cytokine that plays critical roles to define cancer cell phenotypes, construct...
International audienceBackground Transforming growth factor-beta (TGFβ) can limit the efficacy of ca...
TGFβ signaling is associated with non-response to immune checkpoint blockade in patients with advanc...
Recent investigations support an important role for TGF-β in the development of colorectal cancer. H...
The transforming growth factor β (TGFβ) signaling pathway is a key player in metazoan biology, and i...
TGF-β is a pleiotropic cytokine with powerful immunosuppressive functions. Mice deficient for TGF-β1...
Previous studies have suggested that TGF-β functions as a tumor promoter in metastatic, mesenchymal-...
AbstractThe type III TGF-β receptor (TβRIII or betagylcan) is a TGF-β superfamily coreceptor with em...
The type III TGF-β receptor (TβRIII or betagylcan) is a TGF-β superfamily coreceptor with emerging r...
Transforming growth factor-beta1 (TGF-β) regulates a plethora of cell-intrinsic processes that modul...