Blood biomarkers on admission in acute traumatic brain injury: Relations to severity, CT findings and care path in the CENTER-TBI study.
- Czeiter, Endre
- Amrein, Krisztina
- Gravesteijn, Benjamin Y
- Lecky, Fiona
- Menon, David K
- Mondello, Stefania
- Newcombe, Virginia
- Richter, Sophie
- Steyerberg, Ewout W
- Vyvere, Thijs Vande
- Verheyden, Jan
- Xu, Haiyan
- Yang, Zhihui
- Maas, Andrew IR
- Wang, Kevin KW
- Büki, András
- CENTER-TBI Participants and Investigators
DOIAbstract
BACKGROUND: Serum biomarkers may inform and improve care in traumatic brain injury (TBI). We aimed to correlate serum biomarkers with clinical severity, care path and imaging abnormalities in TBI, and explore their incremental value over clinical characteristics in predicting computed tomographic (CT) abnormalities. METHODS: We analyzed six serum biomarkers (S100B, NSE, GFAP, UCH-L1, NFL and t-tau) obtained <24 h post-injury from 2867 patients with any severity of TBI in the Collaborative European NeuroTrauma Effectiveness Research (CENTER-TBI) Core Study, a prospective, multicenter, cohort study. Univariable and multivariable logistic regression analyses were performed. Discrimination was assessed by the area under the receiver operating c...
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