Synthesis, crystal structure and antifungal activity of dihydroisoquinoline Oxaziridines Substitued in Position 1

We report here the synthesis and the X-ray crystallography of dihydroisoquinoline oxaziridines with methyl substitute in position 1 and with nitro group in position 7 (compound 3b). We also synthesized the compound 3a without nitro. These compounds have been prepared by the peracidic oxidation of imines with m-chloroperbenzoic (m-CPBA) like oxidizing agent. This two compounds exhibit higher antifungal activity