Functional effects of the well-characterized antagonist of L-type Ca2+ channels tetrandrine on recombinant human γ-aminobutyric acid type A (GABAA) (α1β2γ2s) receptor or human α7, α4β2, α1β1δγ and α1β1δε nicotinic acetylcholine receptors expressed in Xenopus oocytes were examined using two-electrode voltage clamp. Tetrandrine inhibited the function of acetylcholine nicotinic receptors, but it had no effect on GABAA receptors. Potency of inhibition was influenced by the receptor subtype and the rank order was α4β2\u3eα7\u3eα1β1δγ≅α 1β1δε. Functional inhibition of α4β2 and α1β1δγ receptors was noncompetitive, but only inhibition of α1β1δγ receptors was voltage-dependent. Binding of 125I-α-bungarotoxin to...
AbstractThe highly conserved αLys145 has been suggested to play an important role in the early steps...
The mechanism of action of short-acting, non-depolarising neuromuscular blocking agents at nicotinic...
A study was made on the effects of bicuculline, the classical γ-aminobutyric acid-A receptor antagon...
Functional effects of the well-characterized antagonist of L-type Ca2 + channels tetrandrine on reco...
Effects of derivatives of coclaurine (C), which mimic the \u27eastern\u27 or the nonquaternary halve...
Effects of cytisine (cy), 3-bromocytisine (3-Br-cy), 5-bromocytisine (5-Br-cy) and 3,5-dibromocytisi...
Effects of cytisine (cy), 3-bromocytisine (3-Br-cy), 5-bromocytisine (5-Br-cy) and 3,5-dibromocytis...
1. Human alpha 7 nicotinic acetylcholine (ACh) receptors were expressed in Xenopus oocytes and the e...
The effect of histamine H1 receptor (H1R) antagonists (antihistamines), namely, promethazine (PMZ), ...
Menthol is a common compound in pharmaceutical and commercial products and a popular additive to cig...
Title: Study of pharmacology and function of binding sites of nicotinic acetylcholine receptors Auth...
<p>Nicotinic acetylcholine (ACh) receptors (nAChRs) are included among the targets of a variety of l...
1 Effects of derivatives of coclaurine (C), which mimic the ‘eastern’ or the nonquaternary halves of...
Background: Nondepolarizing neuromuscular blocking agents (NMBAs) are classic competitive-inhibitors...
Choline, the precursor and the metabolite of acetylcholine, is reputed as a selective α7 nicotinic r...
AbstractThe highly conserved αLys145 has been suggested to play an important role in the early steps...
The mechanism of action of short-acting, non-depolarising neuromuscular blocking agents at nicotinic...
A study was made on the effects of bicuculline, the classical γ-aminobutyric acid-A receptor antagon...
Functional effects of the well-characterized antagonist of L-type Ca2 + channels tetrandrine on reco...
Effects of derivatives of coclaurine (C), which mimic the \u27eastern\u27 or the nonquaternary halve...
Effects of cytisine (cy), 3-bromocytisine (3-Br-cy), 5-bromocytisine (5-Br-cy) and 3,5-dibromocytisi...
Effects of cytisine (cy), 3-bromocytisine (3-Br-cy), 5-bromocytisine (5-Br-cy) and 3,5-dibromocytis...
1. Human alpha 7 nicotinic acetylcholine (ACh) receptors were expressed in Xenopus oocytes and the e...
The effect of histamine H1 receptor (H1R) antagonists (antihistamines), namely, promethazine (PMZ), ...
Menthol is a common compound in pharmaceutical and commercial products and a popular additive to cig...
Title: Study of pharmacology and function of binding sites of nicotinic acetylcholine receptors Auth...
<p>Nicotinic acetylcholine (ACh) receptors (nAChRs) are included among the targets of a variety of l...
1 Effects of derivatives of coclaurine (C), which mimic the ‘eastern’ or the nonquaternary halves of...
Background: Nondepolarizing neuromuscular blocking agents (NMBAs) are classic competitive-inhibitors...
Choline, the precursor and the metabolite of acetylcholine, is reputed as a selective α7 nicotinic r...
AbstractThe highly conserved αLys145 has been suggested to play an important role in the early steps...
The mechanism of action of short-acting, non-depolarising neuromuscular blocking agents at nicotinic...
A study was made on the effects of bicuculline, the classical γ-aminobutyric acid-A receptor antagon...