Iptakalim hydrochloride (IPT) is a novel ATP-sensitive potassium (KATP) channel opener which has a different chemical structure from any other known KATP channel opener, and exhibits both blood-brain barrier permeability and little side effects after systemic administration. Emerging lines of evidence indicate that IPT effectively protects brain neurons against glutamate neurotoxicity in in vitro and in vivo animal ischemic/hypoxic models. In addition, IPT has also been shown to serve as a potent compound that protects substantia nigra dopamine neurons against a variety of chemical stresses (e.g., MPP+, 6-OHDA or rotenone) in in vitro and in vivo Parkinson\u27s disease animal models. Possible pharmacological mechanisms of neuroprotection in...
Compound ITH33/IQM9.21 (ITH/IQM) belongs to a new family of L-glutamic acid derivatives with antioxi...
BACKGROUND AND PURPOSE: Alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor inh...
Sulfonylureas have been the leading oral antihyperglycemic agents, and they presently continue to be...
ABSTRACT During cerebral ischemia, the opening of neuronal ATP-sensitive potassium channels (K ATP c...
During cerebral ischemia, the opening of neuronal ATP-sensi-tive potassium channels (KATP channels) ...
Iptakalim, a novel cardiovascular ATP-sensitive K (KATP) chan-nel opener, exerts neuroprotective ef...
Iptakalim is a novel putative adenosine triphosphate (ATP)-sensitive potassium (KATP) channel opener...
Potassium (K+) channels are the most heterogeneous and widely distributed class of ion channels. K+ ...
Arachidonic acids and its metabolites modulate plenty of ligand-gated, voltage-depen-dent ion channe...
International audienceNeuroAid (MLC601 and MLC901), a Traditional Medicine used in China for patient...
Two-pore domain potassium (K2P) channels are expressed in cells throughout the body and give rise to...
Two-pore domain potassium (K2P) channels are expressed in cells throughout the body and give rise to...
Background and Purpose - Mitochondrial ATP-sensitive potassium (mitoKATP) channels are present in th...
Although experimental studies have widely shown that the pharmacological blockade of ionotropic glut...
There is a common belief that the opening of K(+)-ATP channels during an ischemic episode has protec...
Compound ITH33/IQM9.21 (ITH/IQM) belongs to a new family of L-glutamic acid derivatives with antioxi...
BACKGROUND AND PURPOSE: Alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor inh...
Sulfonylureas have been the leading oral antihyperglycemic agents, and they presently continue to be...
ABSTRACT During cerebral ischemia, the opening of neuronal ATP-sensitive potassium channels (K ATP c...
During cerebral ischemia, the opening of neuronal ATP-sensi-tive potassium channels (KATP channels) ...
Iptakalim, a novel cardiovascular ATP-sensitive K (KATP) chan-nel opener, exerts neuroprotective ef...
Iptakalim is a novel putative adenosine triphosphate (ATP)-sensitive potassium (KATP) channel opener...
Potassium (K+) channels are the most heterogeneous and widely distributed class of ion channels. K+ ...
Arachidonic acids and its metabolites modulate plenty of ligand-gated, voltage-depen-dent ion channe...
International audienceNeuroAid (MLC601 and MLC901), a Traditional Medicine used in China for patient...
Two-pore domain potassium (K2P) channels are expressed in cells throughout the body and give rise to...
Two-pore domain potassium (K2P) channels are expressed in cells throughout the body and give rise to...
Background and Purpose - Mitochondrial ATP-sensitive potassium (mitoKATP) channels are present in th...
Although experimental studies have widely shown that the pharmacological blockade of ionotropic glut...
There is a common belief that the opening of K(+)-ATP channels during an ischemic episode has protec...
Compound ITH33/IQM9.21 (ITH/IQM) belongs to a new family of L-glutamic acid derivatives with antioxi...
BACKGROUND AND PURPOSE: Alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor inh...
Sulfonylureas have been the leading oral antihyperglycemic agents, and they presently continue to be...