The Immune Regulatory Role of Cytokine-Induced Killer Cells Treatment on Non-Small Cell Lung Cancer Patients

Although a great progress has been made in surgery, radiotherapy and chemotherapy for non-small cell lung cancer (NSCLC), the 5-year overall survival rate (OS) remains unsatisfactory (approximately 15%). Recently, cytokine-induced killer (CIK) cells treatment as an adoptive immunotherapy has great promises in the scenario of potential new approaches for the treatment of lung tumors. Adaptive and innate cellular immunity are all important for inhibiting tumor growth and the clearance of cancer. The abilities to efficiently kill tumor cells and promote immune responses are the ultimate basic ability requested to CIK cells treatment. Therefore, we conducted a systematic review to evaluate the immunoregulation of CIK cells treatment in NSCLC patients to provide an objective reference for clinical decision-making