The expression of a functional antigen receptor is necessary for cell survival of normal B lymphocytes and most B-cell neoplasms alike. When the genetic modifications of the B-cell receptor locus fail to produce a functional antigen receptor or result in deleterious mutations of a previously expressed receptor, the affected B cell will undergo apoptosis. The three physiological mechanisms that generate the B-cell receptor, VDJ recombination, somatic hypermutation, and class switch recombination, can induce double-strand DNA breaks and can specifically contribute to lymphomagenesis. On the other hand, the B-cell receptor activation and signaling pathways, which provide strong survival and proliferation signals to normal B cells, can support ...
The B-cell receptor (BCR) is of critical importance for normal B cells and for the majority of B-cel...
Toll-like receptors (TLRs) are important players in B-cell activation, maturation and memory and may...
International audienceThe humoral immune system senses microbes via recognition of specific microbia...
University of Minnesota Ph.D. dissertation. July 2009. Major: Molecular, Cellular, Developmental Bio...
Mantle cell lymphoma (MCL) is characterized by an aggressive clinical course and secondary resistanc...
AbstractDuring the last three decades, a number of B-lymphocyte specific surface antigens have been ...
Human B lymphocytes not only play a critical role in the humoral immunity to generate antibodies, bu...
The B-cell receptor (BCR) signaling pathway is a crucial pathway of B cells, both for their survival...
B-cell responses are initiated by the binding of foreign antigens to the clonally distributed B-cell...
Chromosomal translocations involving antigen receptor loci are common in lymphoid malignancies. Tran...
The proper differentiation and survival of human peripheral immature B cells relies on two critical ...
A diverse B-cell receptor (BCR) repertoire is required to bind a wide range of antigens. BCRs are ge...
Surface expression of a functional B cell antigen receptor (BCR) is essential for the survival and p...
Background: Activation of naive B lymphocytes by extracellular ligands, e.g. antigen, lipopolysaccha...
B cells develop from hematopoietic precursor cells in an ordered maturation and selection process. E...
The B-cell receptor (BCR) is of critical importance for normal B cells and for the majority of B-cel...
Toll-like receptors (TLRs) are important players in B-cell activation, maturation and memory and may...
International audienceThe humoral immune system senses microbes via recognition of specific microbia...
University of Minnesota Ph.D. dissertation. July 2009. Major: Molecular, Cellular, Developmental Bio...
Mantle cell lymphoma (MCL) is characterized by an aggressive clinical course and secondary resistanc...
AbstractDuring the last three decades, a number of B-lymphocyte specific surface antigens have been ...
Human B lymphocytes not only play a critical role in the humoral immunity to generate antibodies, bu...
The B-cell receptor (BCR) signaling pathway is a crucial pathway of B cells, both for their survival...
B-cell responses are initiated by the binding of foreign antigens to the clonally distributed B-cell...
Chromosomal translocations involving antigen receptor loci are common in lymphoid malignancies. Tran...
The proper differentiation and survival of human peripheral immature B cells relies on two critical ...
A diverse B-cell receptor (BCR) repertoire is required to bind a wide range of antigens. BCRs are ge...
Surface expression of a functional B cell antigen receptor (BCR) is essential for the survival and p...
Background: Activation of naive B lymphocytes by extracellular ligands, e.g. antigen, lipopolysaccha...
B cells develop from hematopoietic precursor cells in an ordered maturation and selection process. E...
The B-cell receptor (BCR) is of critical importance for normal B cells and for the majority of B-cel...
Toll-like receptors (TLRs) are important players in B-cell activation, maturation and memory and may...
International audienceThe humoral immune system senses microbes via recognition of specific microbia...