Analytical Calibrations: Schemes, Manuals, and Metrological Deliberations

Chemical measurement processes (CMPs) must be performed in a setup of controlled statistical conditions. Thus, validation of such a measurement process and assessment of its ability to accurately measure the analyte is important. Analytical calibration is the most crucial step in any analytical procedure targeting the estimation of analyte concentration. As a key component of any validation procedure, calibration must be properly conducted. To achieve that, firm knowledge with the realms of the calibration process must exist. Several jurisdictions help to build up this acquaintance, including the terminology and definitions, the international guidelines and how they differ, schemes and manuals to be used to build a calibration model, metrological considerations, and assessment procedures. Careful thinking prior to any of the previous calibration aspects is necessary and helps to improve the product of the calibration process. Throughout this chapter, aspects of the calibration assembly will be thoroughly discussed. Different types of calibration will be revealed with a focus on analytical calibration for a CMP. Steps for a successful calibration will be described. The reader will be able to use information given throughout this chapter as a guide for an effective calibration process