Although Gram-negative bacterial pathogens continue to impart a substantial burden on global healthcare systems, much remains to be understood about aspects of basic physiology in these organisms. In recent years, cyclic-diguanylate (c-di-GMP) has emerged as a key regulator of a number of important processes related to pathogenicity, including biofilm formation, motility, and virulence. In an effort to discover chemical genetic probes for studying Vibrio cholerae we have developed a new motility-based high-throughput screen to identify compounds that modulate c-di-GMP levels. Using this new screening platform, we tested a library of microbially derived marine natural products extracts, leading to the discovery of the bioactive lipid (S)-seb...
Humans live in symbiosis with a diverse community of microorganisms, which has evolved to carry out ...
Vibrio spp. are ubiquitous marine bacteria that are ecologically and metabolically diverse members o...
<div><p><i>Vibrio cholerae</i> O1, the etiological agent of cholera, is a natural inhabitant of aqua...
ABSTRACT Vibrio cholerae biofilm formation and associated motility suppression are correlated with i...
This dissertation describes the development and application of a high-throughput, image-based screen...
<div><p>Cyclic-di-GMP (c-di-GMP) is a ubiquitous bacterial signaling molecule that regulates a varie...
As antibiotic resistance among bacterial pathogens continues to escalate, posing an immense threat t...
AbstractThe facultative human pathogen Vibrio cholerae, the causative agent of the severe secretory ...
As antibiotic resistance becomes a major challenge for public health professionals, our research obj...
Vibrio cholerae O1, the etiological agent of cholera, is a natural inhabitant of aquatic ecosystems....
In many bacteria, including Vibrio cholerae, cyclic dimeric guanosine monophosphate (c-di-GMP) contr...
Vibrio cholerae O1, the etiological agent of cholera, is a natural inhabitant of aquatic ecosystems....
Biofilm formation by Vibrio cholerae facilitates environmental persistence, and hyperinfectivity wit...
AAC Accepts, published online ahead of print on 30 July 2012 2 Abstract 24 Bacterial biofilm formati...
Funding for Open Access provided by the UMD Libraries Open Access Publishing Fund.Cyclic-di-GMP (c-d...
Humans live in symbiosis with a diverse community of microorganisms, which has evolved to carry out ...
Vibrio spp. are ubiquitous marine bacteria that are ecologically and metabolically diverse members o...
<div><p><i>Vibrio cholerae</i> O1, the etiological agent of cholera, is a natural inhabitant of aqua...
ABSTRACT Vibrio cholerae biofilm formation and associated motility suppression are correlated with i...
This dissertation describes the development and application of a high-throughput, image-based screen...
<div><p>Cyclic-di-GMP (c-di-GMP) is a ubiquitous bacterial signaling molecule that regulates a varie...
As antibiotic resistance among bacterial pathogens continues to escalate, posing an immense threat t...
AbstractThe facultative human pathogen Vibrio cholerae, the causative agent of the severe secretory ...
As antibiotic resistance becomes a major challenge for public health professionals, our research obj...
Vibrio cholerae O1, the etiological agent of cholera, is a natural inhabitant of aquatic ecosystems....
In many bacteria, including Vibrio cholerae, cyclic dimeric guanosine monophosphate (c-di-GMP) contr...
Vibrio cholerae O1, the etiological agent of cholera, is a natural inhabitant of aquatic ecosystems....
Biofilm formation by Vibrio cholerae facilitates environmental persistence, and hyperinfectivity wit...
AAC Accepts, published online ahead of print on 30 July 2012 2 Abstract 24 Bacterial biofilm formati...
Funding for Open Access provided by the UMD Libraries Open Access Publishing Fund.Cyclic-di-GMP (c-d...
Humans live in symbiosis with a diverse community of microorganisms, which has evolved to carry out ...
Vibrio spp. are ubiquitous marine bacteria that are ecologically and metabolically diverse members o...
<div><p><i>Vibrio cholerae</i> O1, the etiological agent of cholera, is a natural inhabitant of aqua...