Add to ORKGBackground and purpose: The ATP-gated P2X(7) receptor has been shown to play a role in several inflammatory processes, making it an attractive target for anti-inflammatory drug discovery. We have recently identified a novel set of cyclic imide compounds that inhibited P2X(7) receptor-mediated dye uptake in human macrophage THP-1 cells. In this study the actions and selectivity of one of these compounds, AZ11645373, were characterized
ATP acts in the extracellular environment as an important signal, activating a family of receptors c...
A review. The P2X7 receptor is involved in several processes relevant to inflammation (cytokine rel...
The purinergic P2X7 receptor is a unique member of the ATP-gated P2X family. This receptor has been ...
P2X7 is an extracellular adenosine 5′-triphopshate (ATP)-gated cation channel present on leukocytes,...
The ionotropic P2X7 receptor (P2X7R) has become the focus of intense research interest for a number ...
P2X4 and P2X7 receptors are ATP-gated ion channels, which play important roles in neuropathic and in...
Abstract The P2X(7) receptor is involved in several processes relevant to inflammation (cytokine re...
The P2X7 receptor (P2X7R) is a nonselective cation channel that is activated by extracellular ATP an...
The ability of P2 antagonists to affect agonist-stimulated fluores-cent dye accumulation in cells ex...
Background: The P2X7 receptor is present in a variety of cell types involved in pain, inflammatory p...
A panel of 18 protein tyrosine kinase antagonists were tested for their inhibitory effect on human P...
The P2X7 receptor (P2X7R) is a ligand gated ion channel activated by high concentrations of ATP that...
The P2X7 receptor (P2X7R) is a purinergic receptor that plays a central role in the inflammatory res...
The P2X7 receptor (P2X7R) is a trimeric ligand-gated ion channel which is activated by ATP. It is im...
ABSTRACT BACKGROUND AND AIMS: The P2X7 receptor (P2X7R) is an ATP-gated, non-selective cation channe...
ATP acts in the extracellular environment as an important signal, activating a family of receptors c...
A review. The P2X7 receptor is involved in several processes relevant to inflammation (cytokine rel...
The purinergic P2X7 receptor is a unique member of the ATP-gated P2X family. This receptor has been ...
P2X7 is an extracellular adenosine 5′-triphopshate (ATP)-gated cation channel present on leukocytes,...
The ionotropic P2X7 receptor (P2X7R) has become the focus of intense research interest for a number ...
P2X4 and P2X7 receptors are ATP-gated ion channels, which play important roles in neuropathic and in...
Abstract The P2X(7) receptor is involved in several processes relevant to inflammation (cytokine re...
The P2X7 receptor (P2X7R) is a nonselective cation channel that is activated by extracellular ATP an...
The ability of P2 antagonists to affect agonist-stimulated fluores-cent dye accumulation in cells ex...
Background: The P2X7 receptor is present in a variety of cell types involved in pain, inflammatory p...
A panel of 18 protein tyrosine kinase antagonists were tested for their inhibitory effect on human P...
The P2X7 receptor (P2X7R) is a ligand gated ion channel activated by high concentrations of ATP that...
The P2X7 receptor (P2X7R) is a purinergic receptor that plays a central role in the inflammatory res...
The P2X7 receptor (P2X7R) is a trimeric ligand-gated ion channel which is activated by ATP. It is im...
ABSTRACT BACKGROUND AND AIMS: The P2X7 receptor (P2X7R) is an ATP-gated, non-selective cation channe...
ATP acts in the extracellular environment as an important signal, activating a family of receptors c...
A review. The P2X7 receptor is involved in several processes relevant to inflammation (cytokine rel...
The purinergic P2X7 receptor is a unique member of the ATP-gated P2X family. This receptor has been ...