Immunotherapy of HIV-1 Infection

A number of lines of evidence suggest that immunotherapy with the cytokine interleukin-2 (IL-2) may boost the immune response to fight HIV infection. CD4+ T cells, the cells which orchestrate the immune response, are also the cells that become infected by the HIV virus. These cells use cytokines as signaling mechanisms for immune-response stimulation, growth, and differentiation. Since CD4+ T cells are hampered due to HIV infection, normal signaling, and the resulting cascade, may not occur. Introduction of IL-2 into the system can restore or enhance these effects. We illustrate, through mathematical modeling, the effects of IL-2 treatment on an HIV-infected patient. With good comparison to existing clinical data, we can better understand what mechanisms of immune-viral dynamics are necessary to produce the typical disease dynamics.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/83697/1/Kirschner-JBS-1998.pd