Relationship of vitamin D and parathyroid hormone with obesity and body composition in African Americans

Obesity disproportionately affects African Americans (AA) (especially women), and is linked to depressed 25-hydroxyvitamin D (25-OH D) and elevated parathyroid hormone (PTH). The relationship of 25-OH D and PTH with body composition and size in AA is not well known.To determine the relationship of 25-OH D and PTH levels with body composition and anthropometric measures.A cross-sectional study was conducted in 98 healthy, overweight, adult AA enrolled in an NIH/NIEHS-sponsored weight loss/salt-sensitivity trial.Multivariable linear regression analyses were used to explore the relationship of 25-OH D and PTH with body composition, determined by dual-energy X-ray absorptiometry, and anthropometric measures. Body composition and size were contrasted across vitamin D/PTH groups using general linear models: (i) normal (25-OH D >50 nmol/l, PTH ≤65 pg/ml), (ii) low 25-OH D and normal PTH and (iii) low 25-OH D and high PTH.Age, gender and season-adjusted regression analyses showed that PTH was directly correlated with total ( P = 0·02), truncal ( P = 0·03) and extremity ( P = 0·03) fat mass, while 25-OH D was inversely related to truncal fat mass ( P = 0·02). Total fat mass in groups 1–3, respectively, was 30·0, 34·0 and 37·4 kg ( P = 0·008); truncal fat mass was 13·4, 15·9 and 17·6 kg ( P = 0·006) and extremity fat mass was 15·8, 16·9 and 19·7 kg ( P = 0·02). Lean mass did not differ across the three groups.Our findings show that lower 25-OH D and raised PTH are both correlated, though in opposite directions, with fat mass, fat distribution and anthropometric measures in adult AA.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/79084/1/j.1365-2265.2009.03676.x.pd