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Molecular defects in coagulation Factor VIII and their impact on Factor VIII function

Saenko, E. L.
Ananyeva, N.M.
Kouiavskaia, D.
Schwinn, H.
Josic, D.
Shima, M.
Hauser, C. A. E.
Pipe, Steven W.

Publication date

August 2002

DOI

10.1046/j.1423-0410.2002.00183.x

Publisher

Wiley

ISSN

0042-9007

Journal

Vox Sanguinis

Language

English

Citation count (estimate)

12

Abstract

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/74861/1/j.1423-0410.2002.00183.x.pd

Extracted data

Related items

The Tertiary Structure and Domain Organization of Coagulation Factor VIII

Spiegel, P. Clint
Shen, Betty W.
Chang, Chong-Hwan
Huh, Jae-Wook
Kim, Jeanman
Kim, Young-Ho
Stoddard, Barry L.

February 2008

Factor VIII (fVIII) is a serum protein in the coagulation cascade that nucleates the assembly of a m...

An engineered interdomain disulfide bond stabilizes human blood coagulation factor VIIIa

Gale, Andrew,
Pellequer, Jean-Luc

April 2003

International audienceThe blood coagulation disorder, hemophilia A, is caused by de®ciency of coagul...

Functional regions in coagulation factor VIII explored by mass spectrometry

Bloem, E.

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The molecular mechanisms behind the function of factor VIII (FVIII) have remained poorly understood....

Functional roles of the factor VIII B domain

Pipe, Steven W.

November 2009

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/74800/1/j.1365-2516.2009.02026.x.pd

Structural Characterization of Factor VIII-Inhibitor Complexes and Factor VIII Lipid Binding Mechanics

Mitchell, Corbin

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Structural Characterization of Factor VIII-Inhibitor Complexes and Factor VIII Lipid Binding Mechanics

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Contributions of Active Site Docking and Exosite Binding to the Mechanism of Thrombin-Catalyzed Activation of Factor VIII

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Normal blood clotting is regulated by blood plasma protein factors in a blood coagulation cascade. D...

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January 2012

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/90346/1/j.1538-7836.2011.04545.x.pd

Mild/moderate haemophilia A: new insights into molecular mechanisms and inhibitor development

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An engineered interdomain disulfide bond stabilizes human blood coagulation factor VIIIa

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International audienceThe blood coagulation disorder, hemophilia A, is caused by de®ciency of coagul...

Structure of the Human Factor VIII C2 Domain in Complex with the 3E6 Inhibitory Antibody.

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Wuerth, Michelle E.
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Blood coagulation factor VIII is a glycoprotein cofactor that is essential for the intrinsic pathway...

The Tertiary Structure and Domain Organization of Coagulation Factor VIII

Spiegel, P. Clint
Shen, Betty W.
Chang, Chong-Hwan
Huh, Jae-Wook
Kim, Jeanman
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Stoddard, Barry L.

February 2008

Factor VIII (fVIII) is a serum protein in the coagulation cascade that nucleates the assembly of a m...

An engineered interdomain disulfide bond stabilizes human blood coagulation factor VIIIa

Gale, Andrew,
Pellequer, Jean-Luc

April 2003

International audienceThe blood coagulation disorder, hemophilia A, is caused by de®ciency of coagul...

Functional regions in coagulation factor VIII explored by mass spectrometry

Bloem, E.

May 2013

The molecular mechanisms behind the function of factor VIII (FVIII) have remained poorly understood....

Functional roles of the factor VIII B domain

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November 2009

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/74800/1/j.1365-2516.2009.02026.x.pd

Structural Characterization of Factor VIII-Inhibitor Complexes and Factor VIII Lipid Binding Mechanics

Mitchell, Corbin

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Blood coagulation factor VIII (FVIII) is a crucial protein cofactor within the blood coagulation cas...

Structural Characterization of Factor VIII-Inhibitor Complexes and Factor VIII Lipid Binding Mechanics

Mitchell, Corbin

January 2022

Blood coagulation factor VIII (FVIII) is a crucial protein cofactor within the blood coagulation cas...

Contributions of Active Site Docking and Exosite Binding to the Mechanism of Thrombin-Catalyzed Activation of Factor VIII

Newell, Jennifer Lynn
Fay, Philip J.

September 2012

Thesis (Ph.D.)--University of Rochester. School of Medicine and Dentistry. Dept. of Biochemistry and...

Structural studies of blood coagulation factor VIII in complexes with inhibitory antibodies

Werther, Rachel

January 2012

Normal blood clotting is regulated by blood plasma protein factors in a blood coagulation cascade. D...

Bioengineering of coagulation factor VIII for efficient expression through elimination of a dispensable disulfide loop

Selvaraj, S. R.
Scheller, A. N.
Miao, H. Z.
Kaufman, R. J.
Pipe, Steven W.

January 2012

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/90346/1/j.1538-7836.2011.04545.x.pd

Mild/moderate haemophilia A: new insights into molecular mechanisms and inhibitor development

D’oiron, R.
Pipe, Steven W.
Jacquemin, M.

July 2008

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/72987/1/j.1365-2516.2008.01730.x.pd

Haemophilia A and von Willebrand's disease.

Goodeve, A.C.
Rosen, S.
Verbruggen, B.

January 2010

Contains fulltext : 88434.pdf (publisher's version ) (Closed access)SUMMARY: Defic...

Lipid Binding Studies of Blood Coagulation Factor VIII C1 and C2 Domains

Blazevic, Rachel

May 2017

Blood coagulation factor VIII is an essential cofactor in the mammalian blood-clotting cascade. FVII...

Crystal Structure of Human Factor VIII: Implications for the Formation of the Factor IXa-Factor VIIIa Complex

Ngo, Jacky Chi Ki
Huang, Mingdong
Roth, David A.
Furie, Barbara C.
Furie, Bruce

April 2008

SummaryFactor VIII is a procofactor that plays a critical role in blood coagulation, and is missing ...

An engineered interdomain disulfide bond stabilizes human blood coagulation factor VIIIa

Gale, Andrew, J
Pellequer, Jean-Luc

April 2003

International audienceThe blood coagulation disorder, hemophilia A, is caused by de®ciency of coagul...

Structure of the Human Factor VIII C2 Domain in Complex with the 3E6 Inhibitory Antibody.

Spiegel, P. Clint
Wuerth, Michelle E.
Cragerud, Rebecca K.

November 2015

Blood coagulation factor VIII is a glycoprotein cofactor that is essential for the intrinsic pathway...

The Tertiary Structure and Domain Organization of Coagulation Factor VIII

Spiegel, P. Clint
Shen, Betty W.
Chang, Chong-Hwan
Huh, Jae-Wook
Kim, Jeanman
Kim, Young-Ho
Stoddard, Barry L.

February 2008

Factor VIII (fVIII) is a serum protein in the coagulation cascade that nucleates the assembly of a m...

An engineered interdomain disulfide bond stabilizes human blood coagulation factor VIIIa

Gale, Andrew,
Pellequer, Jean-Luc

April 2003

International audienceThe blood coagulation disorder, hemophilia A, is caused by de®ciency of coagul...

Functional regions in coagulation factor VIII explored by mass spectrometry

Bloem, E.

May 2013

The molecular mechanisms behind the function of factor VIII (FVIII) have remained poorly understood....