In vivo and in vitro Activation of T-Antigen Receptors on Leukocytes and Platelets 1

Serological studies on a patient whose red cells are polyagglutinable due to T activation have demonstrated concomitant T activity of the separated leukocytes and platelets. Normal leukocytes and platelets are not T active, but activation can be induced in vitro by treatment with neuraminidase or with Pneumo-coccus type III filtrate. Such T-active cells absorb anti-T from Arachis hypogea lectin. Tests on different types of separated leukocytes show that both neutrophils and lymphocytes have latent T antigen receptors. Neuraminidase treatment of platelets does not change their ability to promote clot retraction, to aggregate with ADP, or to take up serotonin.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/73987/1/j.1423-0410.1976.tb02217.x.pd