The frequency in Japanese of genetic variants of 22 proteins: IV. Acid phosphatase, NADP-isocitrate dehydrogenase, peptidase A, peptidase B and phosphohexose isomerase

This paper presents the results of an electrophoretic survey of approximately 4000 individuals from Hiroshima and Nagasaki for four erythrocyte enzymes: isocitrate dehydrogenase, pepti- dase A, peptidase B, and phosphohexose isomerase. Also reported are the results for erythrocyte acid phosphatase for a subset of these individuals. The frequencies for the ACPf and ACPF alleles of the ACP, locus are in agreement with previously reported results from Japanese populations. Rare variants of ICD, PEPA, PEPB and PHI occur with frequencies varying from 0.25 to 7.2 per 1000 determinations. The relatively high frequency of the PHI 4RIR1 variant and some unusual features involving the effect of reducing agent on the electrophoretic pattern behaviour of some of the rare PHI variants detected during this study are discussed.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/65914/1/j.1469-1809.1978.tb00912.x.pd