Visfatin is a cytokine hormone and an enzyme involved in metabolic (obesity, type II diabetes) and immune disorders. Some data suggest a role of visfatin in ovarian function. Here, we identified visfatin in human follicles and investigated the molecular mechanisms involved in the regulation of its expression in response to insulin sensitizers, metformin (MetF) and rosiglitazone, in primary human granulosa cells (hGCs) and in a human ovarian granulosa-like tumour cell line (KGN). We also studied the effects of human recombinant visfatin (RhVisf) on steroid production and on the activation of various signalling pathways. By RT-PCR, immunoblotting and immunohistochemistry, we showed that visfatin is expressed not only in hGCs and KGN cells, bu...
Tumor necrosis factor α (TNFα) is a well-known mediator of inflammation in the context of obesity in...
Objectives: To elucidate the main source of circulating visfatin and its potential roles in pathogen...
Obesity is a cancer progression risk factor; excessive adipocytes increase adipokine secretion. Visf...
Visfatin is expressed in human granulosa cells: regulation by metformin through AMPK/SIRT1 pathways ...
VISFATIN is a novel adipokine, also known as a Nicotinamide phosphorybosyltransferase (NAMPT) that i...
The role of the adipocyte-derived factor visfatin in metabolism remains controversial, although some...
The role of the adipocyte-derived factor visfatin in metabolism remains controversial, although some...
AbstractVisfatin was originally identified as a growth factor for immature B cells, and recently dem...
The expression of visfatin in ovary and the changes of IFN-γ in peripheral blood were detected by th...
Obesity is associated with higher postmenopausal breast cancer incidence. Visfatin level alteration ...
Visfatin has been proposed as an insulin-mimicking adipocytokine, predominantly secreted from adipos...
Visfatin has been proposed as an insulin-mimicking adipocytokine, predominantly secreted from adipos...
Context: Polycystic ovary syndrome (PCOS) is a multifaceted metabolic disease linked with insulin re...
Visfatin is a multifaceted adipokine whose circulating levels are enhanced in different metabolic di...
BACKGROUND:Visfatin is a multifaceted adipokine whose circulating levels are enhanced in different m...
Tumor necrosis factor α (TNFα) is a well-known mediator of inflammation in the context of obesity in...
Objectives: To elucidate the main source of circulating visfatin and its potential roles in pathogen...
Obesity is a cancer progression risk factor; excessive adipocytes increase adipokine secretion. Visf...
Visfatin is expressed in human granulosa cells: regulation by metformin through AMPK/SIRT1 pathways ...
VISFATIN is a novel adipokine, also known as a Nicotinamide phosphorybosyltransferase (NAMPT) that i...
The role of the adipocyte-derived factor visfatin in metabolism remains controversial, although some...
The role of the adipocyte-derived factor visfatin in metabolism remains controversial, although some...
AbstractVisfatin was originally identified as a growth factor for immature B cells, and recently dem...
The expression of visfatin in ovary and the changes of IFN-γ in peripheral blood were detected by th...
Obesity is associated with higher postmenopausal breast cancer incidence. Visfatin level alteration ...
Visfatin has been proposed as an insulin-mimicking adipocytokine, predominantly secreted from adipos...
Visfatin has been proposed as an insulin-mimicking adipocytokine, predominantly secreted from adipos...
Context: Polycystic ovary syndrome (PCOS) is a multifaceted metabolic disease linked with insulin re...
Visfatin is a multifaceted adipokine whose circulating levels are enhanced in different metabolic di...
BACKGROUND:Visfatin is a multifaceted adipokine whose circulating levels are enhanced in different m...
Tumor necrosis factor α (TNFα) is a well-known mediator of inflammation in the context of obesity in...
Objectives: To elucidate the main source of circulating visfatin and its potential roles in pathogen...
Obesity is a cancer progression risk factor; excessive adipocytes increase adipokine secretion. Visf...