International audienceThe GTPase dynamin polymerizes into a helical coat that constricts membrane necks of endocytic pits to promote their fission. However, the dynamin mechanism is still debated because constriction is necessary but not sufficient for fission. Here, we show that fission occurs at the interface between the dynamin coat and the uncoated membrane. At this location, the considerable change in membrane curvature increases the local membrane elastic energy, reducing the energy barrier for fission. Fission kinetics depends on tension, bending rigidity, and the dynamin constriction torque. Indeed, we experimentally find that the fission rate depends on membrane tension in vitro and during endocytosis in vivo. By estimating the ene...
The generation of membrane curvature in intracellular traffic involves many proteins that can curve ...
Dynamin is a large GTPase that forms a helical collar at the neck of endocytic pits, and catalyzes m...
SummaryThe GTPase dynamin assembles at the necks of budded vesicles in vivo and functions in membran...
International audienceThe GTPase dynamin polymerizes into a helical coat that constricts membrane ne...
SummaryThe GTPase dynamin polymerizes into a helical coat that constricts membrane necks of endocyti...
The GTPase dynamin polymerizes into a helical coat that constricts membrane necks of endocytic pits ...
SummaryThe GTPase dynamin polymerizes into a helical coat that constricts membrane necks of endocyti...
Membrane fission is required for vesicular traffic between intracellular compartments. Dynamin is a ...
In eukaryotic cells, membrane compartments are split into two by membrane fission. This ensures disc...
The eukaryotic cell is organized in several compartments, named organelles, delimited by lipid membr...
The eukaryotic cell is organized in several compartments, named organelles, delimited by lipid membr...
International audienceDuring membrane fission, the GTPase dynamin forms helical assemblies at the ne...
During membrane fission, the GTPase dynamin forms helical assemblies at the neck of membrane buds. A...
SummaryThe GTPase dynamin is critically involved in membrane fission during endocytosis. How does dy...
SummaryThe GTPase dynamin is critically involved in membrane fission during endocytosis. How does dy...
The generation of membrane curvature in intracellular traffic involves many proteins that can curve ...
Dynamin is a large GTPase that forms a helical collar at the neck of endocytic pits, and catalyzes m...
SummaryThe GTPase dynamin assembles at the necks of budded vesicles in vivo and functions in membran...
International audienceThe GTPase dynamin polymerizes into a helical coat that constricts membrane ne...
SummaryThe GTPase dynamin polymerizes into a helical coat that constricts membrane necks of endocyti...
The GTPase dynamin polymerizes into a helical coat that constricts membrane necks of endocytic pits ...
SummaryThe GTPase dynamin polymerizes into a helical coat that constricts membrane necks of endocyti...
Membrane fission is required for vesicular traffic between intracellular compartments. Dynamin is a ...
In eukaryotic cells, membrane compartments are split into two by membrane fission. This ensures disc...
The eukaryotic cell is organized in several compartments, named organelles, delimited by lipid membr...
The eukaryotic cell is organized in several compartments, named organelles, delimited by lipid membr...
International audienceDuring membrane fission, the GTPase dynamin forms helical assemblies at the ne...
During membrane fission, the GTPase dynamin forms helical assemblies at the neck of membrane buds. A...
SummaryThe GTPase dynamin is critically involved in membrane fission during endocytosis. How does dy...
SummaryThe GTPase dynamin is critically involved in membrane fission during endocytosis. How does dy...
The generation of membrane curvature in intracellular traffic involves many proteins that can curve ...
Dynamin is a large GTPase that forms a helical collar at the neck of endocytic pits, and catalyzes m...
SummaryThe GTPase dynamin assembles at the necks of budded vesicles in vivo and functions in membran...