Straightfoward synthesis of 2-acetyl-substituted benzo[b]thiophenes

International audienceDescribed herein is a green one-step protocol for the preparation of substituted 2-acetylbenzo[b]thiophenes from commercially available aromatic halides. This efficient method has the advantage of using water as the reaction medium, resulting in a high yield of pure cyclized products. Two scaffold types have been prepared using this general procedure: 2-acetylbenzo[b]thiophenes and 2-acetyl-3-aminobenzo[b]thiophenes, both crystallized directly from the reaction mixture, due to their low solubility with water, and without the need for an additional purification step. ChemInform Abstract: Straightforward Synthesis of 2-Acetyl-Substituted Benzo[b]thiophenes. - ResearchGate. Available from: http://www.researchgate.net/publication/264576761_ChemInform_Abstract_Straightforward_Synthesis_of_2-Acetyl-Substituted_Benzobthiophenes [accessed Apr 28, 2015]