A quantitative approach for studying the bioactivity of nano-hydroxyapatite composites

International audienceThis work describes a quantitative kinetic approach to assess the in-vitro bioactivity of gold-doped hydroxyapatite-polyvinyl alcohol nanocomposites. The surface morphology of the in-situ prepared nanocomposites as characterized by Transmission Electron Microscopy (TEM) revealed a rod-like shape. Differential Thermal Analysis-Thermogravimetric (DTA-TG) and Fourier Transformed Infrared Spectroscopy (FT-IR) as well as zeta potential measurements of the prepared nanocomposites were carried out. Uptake profiles of Ca and P were studied onto nanocomposites of different gold concentrations after their soaking in simulated body fluid (SBF) and they best followed the pseudo second-order kinetic model. The highest uptakes of both Ca and P were obtained using the nanocomposite with the lowest concentration of gold. Furthermore, sorption mechanism was described by the intra-particle diffusion model where pore diffusion was found to be the rate limiting step. The prepared nanocomposites have promising potential in orthopaedic and tissue engineering applications due to their high capacity and fast uptake for Ca and P which form apatite. This article is protected by copyright. All rights reserved.[on SciFinder (R)