Genetic analysis of the alpha2-macroglobulin gene in early- and late-onset Parkinson's disease.

Genetic predisposition to weight loss and regain with lifestyle intervention: Analyses from the Diabetes Prevention Program and the Look AHEAD randomized controlled trials.

Papandonatos, G.D.
Pan, Q.
Pajewski, N.M.
Delahanty, L.M.
Peter, I.
Erar, B.
Ahmad, S.
Harden, M.
Chen, L.
Fontanillas, P.
GIANT Consortium (Albrecht, E.
Wagenknecht, L.E.
Kahn, S.E.
Wing, R.R.
Jablonski, K.A.
Huggins, G.S.
Knowler, W.C.
Florez, J.C
McCaffery, J.M.
Franks, P.W.
Diabetes Prevention Program ()
Look AHEAD Research Group ()

January 2015

We investigated the genetic overlap between Alzheimer’s disease (AD) and Parkinson’s dis...

Genetic overlap between Alzheimer's disease and Parkinson's disease at the MAPT locus.

Desikan, RS
Schork, AJ
Wang, Y
Witoelar, A
Sharma, M
McEvoy, LK
Holland, D
Brewer, JB
Chen, C-H
Thompson, WK
Harold, D
Williams, J
Owen, MJ
O'Donovan, MC
Pericak-Vance, MA
Mayeux, R
Haines, JL
Farrer, LA
Schellenberg, GD
Heutink, P
Singleton, AB
Brice, A
Wood, NW
Hardy, J
Martinez, M
Choi, SH
DeStefano, A
Ikram, MA
Bis, JC
Smith, A
Fitzpatrick, AL
Launer, L
van Duijn, C
Seshadri, S
Ulstein, ID
Aarsland, D
Fladby, T
Djurovic, S
Hyman, BT
Snaedal, J
Stefansson, H
Stefansson, K
Gasser, T
Andreassen, OA
Dale, AM
ADNI, ADGC, GERAD, CHARGE and IPDGC Investigators

December 2015

We investigated the genetic overlap between Alzheimer's disease (AD) and Parkinson's disease (PD). U...

Rare variants in beta-Amyloid precursor protein (APP) and Parkinson's disease.

Schulte EC
Fukumori A
Mollenhauer B
Hor H
Arzberger T
Perneczky R
Kurz A
Diehl-Schmid J
Hull M
Lichtner P
Eckstein G
Zimprich A
Haubenberger D
Pirker W
Brucke T
Bereznai Benjamin
Molnar Mária Judit
Lorenzo-Betancor O
Pastor P
Peters A
Gieger C
Estivill X
Meitinger T
Kretzschmar HA
Trenkwalder C
Haass C
Winkelmann J

March 2019

Many individuals with Parkinson's disease (PD) develop cognitive deficits, and a phenotypic and mole...

Genetic analysis of the alpha2-macroglobulin gene in early- and late-onset Parkinson's disease.

Krüger, Rejko
Menezes-Saecker, A. M.
Schols, L.
Kuhn, W.
Muller, T.
Woitalla, D.
Berg, D.
Berger, K.
Przuntek, H.
Epplen, J. T.
Riess, O.

January 2000

peer reviewedRecent association studies investigating polymorphisms in the alpha2-macroglobulin (A2M...

Genetic association of an (α2-macroglobulin (Val1000lle) polymorphism and Alzheimer's disease

Liao, A.
Nitsch, R. M.
Greenberg, S. M.
Finckh, U.
Blacker, D.
Albert, M.
Rebeck, G. W.
Gomez-Isla, T.
Clatworthy, A.
Binetti, G.
Hock, C.
Mueller-Thomsen, T.
Mann, U.
Zuchowski, K.
Beisiegel, U.
Staehelin, H.
Growdon, J. H.
Tanzi, R. E.
Hyman, B. T.

August 2017

α2-Macroglobulin (A2M) is a proteinase inhibitor found in association with senile plaques (SP) in Al...

Alpha2-macroglobulin polymorphisms in Italian sporadic and familial Alzheimer's disease

Nacmias, B
Tedde, A
Cellini, E
Forleo, P
Guarnieri, B
Petruzzi, C
D'Andrea, F
Serio, A
Sorbi, S.
ORLACCHIO, ANTONIO

February 2001

A 5-bp deletion and a Val1000 polymorphism at the alpha(2)-macroglobulin (A2M) gene have recently be...

alfa2-Macroglobulin deletion polymorphism and plasma levels in late-onset Alzheimer’s disease

Scacchi, R.
Ruggeri, M.
Gambina, G
Martini, M. C.
Corbo, Rosa Maria

January 2002

The acute-phase "panproteinase" inhibitor "2-macroglobulin (alpha2M), a protein involved in inflamma...

No association between the alpha2-macroglobulin (A2M) deletion and Alzheimer's disease, and no change in A2M mRNA, protein, or protein expression

Blennow, K
Ricksten, A
Prince, J A
Brookes, A J
Emahazion, T
Wasslavik, C
Bogdanovic, N
Andreasen, N
Batsman, S
Marcusson, J
Nägga, Katarina
Wallin, A
Regland, B
Olofsson, H
Hesse, C
Davidsson, P
Minthon, Lennart
Jansson, A
Palmqvist, L
Rymo, L

January 2000

A polymorphism consisting of a deletion near the 5' splice site of exon 18 on the alpha2-macroglobul...

Analysis of genome-wide association studies of Alzheimer disease and of Parkinson disease to determine if these 2 diseases share a common genetic risk

Escott-Price, Valentina
Harold, Denise
Russo, Giancarlo
Vedernikov, Alexey
Sharma, Manu
Saad, Mohamad
Holmans, Peter Alan
Bras, Jose M.
Bettella, Francesco
Keller, Margaux F.
Nicolaou, Nayia
Simón-Sánchez, Javier
Gibbs, J. Raphael
Schulte, Claudia
Durr, Alexandra
Guerreiro, Rita
Hernandez, Dena
Brice, Alexis
Stefánsson, Hreinn
Majamaa, Kari
Gasser, Thomas
Heutink, Peter
Wood, Peter
Martinez, Maria
Singleton, Andrew B.
Nalls, Michael A.
Hardy, John
Owen, Michael John
O’Donovan, Michael Conlon
Williams, Julie
Morris, Huw
Williams, Nigel Melville

January 2013

.Importance Despite Alzheimer disease (AD) and Parkinson disease (PD) being clinically distinct enti...

Sequence variation in the proximity of IDE may impact age at onset of both Parkinson disease and Alzheimer disease

Blomqvist, MEL
Silburn, PA
Buchanan, DD
Andreasen, N
Blennow, K
Pedersen, NL
Brookes, AJ
Mellick, GD
Prince, JA

January 2004

We recently reported that a linkage disequilibrium (LD) block on chromosome 10q encompassing the gen...

Increased susceptibility to sporadic Parkinson's disease by a certain combined alpha-synuclein/apolipoprotein E genotype.

Krüger, Rejko
Vieira-Saecker, A. M.
Kuhn, W.
Berg, D.
Muller, T.
Kuhnl, N.
Fuchs, G. A.
Storch, A.
Hungs, M.
Woitalla, D.
Przuntek, H.
Epplen, J. T.
Schols, L.
Riess, O.

January 1999

Parkinson's disease (PD) is one of the most common neurodegenerative disorders affecting about 1% of...

Genomewide Association Study for Onset Age in Parkinson Disease

Latourelle, Jeanne C.
Pankratz, Nathan
Dumitriu, Alexandra
Wilk, Jemma B.
Goldwurm, Stefano
Pezzoli, Gianni
Mariani, Claudio B.
DeStefano, Anita L.
Halter, Cheryl
Gusella, James F.
Nichols, William C.
Myers, Richard H.
Foroud, Tatiana

September 2009

BACKGROUND: Age at onset in Parkinson disease (PD) is a highly heritable quantitative trait for whic...

The α2-macroglobulin gene in AD: a population-based study and meta-analysis

Koster, MN
Dermaut, Bart
Cruts, M
Houwing-Duistermaat, JJ
Roks, G
Tol, J
Ott, A
Hofman, A
Munteanu, G
Breteler, MMB
van Duijn, CM
Van Broeckhoven, C

January 2000

Background: Whereas several authors recently reported a positive association between the alpha 2-mac...

Modulation of disease risk according to a cathepsin D / apolipoprotein E genotype in Parkinson's disease.

Schulte, T.
Bohringer, S.
Schols, L.
Muller, T.
Fischer, C.
Riess, O.
Przuntek, H.
Berger, K.
Epplen, J. T.
Krüger, Rejko

January 2003

peer reviewedAspartyl protease Cathepsin D (CTSD) has been suggested to play a role in the pathogene...

No association between the alpha-2 macroglobulin I1000V polymorphism and Alzheimer's disease

Wavrant-DeVrieze, F.
Rudrasingham, V.
Lambert, J. C.
Chakraverty, S.
Kehoe, P.
Crook, R.
Amouyel, P.
Wu, W.
Holmans, Peter Alan
Rice, Frances
Perez-Tur, J.
Frigard, B.
Morric, J. C.
Carty, S.
Cottel, D.
Tunstall, N.
Lovestone, S.
Petersen, R. C.
Chartier-Harlin, M. C.
Goate, A.
Owen, Michael John
Williams, Julie
Hardy, J.

March 1999

Recent reports have suggested that variability in the alpha2-macroglobulin gene is a genetic risk fa...

Genetic predisposition to weight loss and regain with lifestyle intervention: Analyses from the Diabetes Prevention Program and the Look AHEAD randomized controlled trials.

Papandonatos, G.D.
Pan, Q.
Pajewski, N.M.
Delahanty, L.M.
Peter, I.
Erar, B.
Ahmad, S.
Harden, M.
Chen, L.
Fontanillas, P.
GIANT Consortium (Albrecht, E.
Wagenknecht, L.E.
Kahn, S.E.
Wing, R.R.
Jablonski, K.A.
Huggins, G.S.
Knowler, W.C.
Florez, J.C
McCaffery, J.M.
Franks, P.W.
Diabetes Prevention Program ()
Look AHEAD Research Group ()

January 2015

We investigated the genetic overlap between Alzheimer’s disease (AD) and Parkinson’s dis...

Genetic overlap between Alzheimer's disease and Parkinson's disease at the MAPT locus.

Desikan, RS
Schork, AJ
Wang, Y
Witoelar, A
Sharma, M
McEvoy, LK
Holland, D
Brewer, JB
Chen, C-H
Thompson, WK
Harold, D
Williams, J
Owen, MJ
O'Donovan, MC
Pericak-Vance, MA
Mayeux, R
Haines, JL
Farrer, LA
Schellenberg, GD
Heutink, P
Singleton, AB
Brice, A
Wood, NW
Hardy, J
Martinez, M
Choi, SH
DeStefano, A
Ikram, MA
Bis, JC
Smith, A
Fitzpatrick, AL
Launer, L
van Duijn, C
Seshadri, S
Ulstein, ID
Aarsland, D
Fladby, T
Djurovic, S
Hyman, BT
Snaedal, J
Stefansson, H
Stefansson, K
Gasser, T
Andreassen, OA
Dale, AM
ADNI, ADGC, GERAD, CHARGE and IPDGC Investigators

December 2015

We investigated the genetic overlap between Alzheimer's disease (AD) and Parkinson's disease (PD). U...

Rare variants in beta-Amyloid precursor protein (APP) and Parkinson's disease.

Schulte EC
Fukumori A
Mollenhauer B
Hor H
Arzberger T
Perneczky R
Kurz A
Diehl-Schmid J
Hull M
Lichtner P
Eckstein G
Zimprich A
Haubenberger D
Pirker W
Brucke T
Bereznai Benjamin
Molnar Mária Judit
Lorenzo-Betancor O
Pastor P
Peters A
Gieger C
Estivill X
Meitinger T
Kretzschmar HA
Trenkwalder C
Haass C
Winkelmann J

March 2019

Many individuals with Parkinson's disease (PD) develop cognitive deficits, and a phenotypic and mole...

Genetic analysis of the alpha2-macroglobulin gene in early- and late-onset Parkinson's disease.

Krüger, Rejko
Menezes-Saecker, A. M.
Schols, L.
Kuhn, W.
Muller, T.
Woitalla, D.
Berg, D.
Berger, K.
Przuntek, H.
Epplen, J. T.
Riess, O.

January 2000

peer reviewedRecent association studies investigating polymorphisms in the alpha2-macroglobulin (A2M...

Genetic association of an (α2-macroglobulin (Val1000lle) polymorphism and Alzheimer's disease

Liao, A.
Nitsch, R. M.
Greenberg, S. M.
Finckh, U.
Blacker, D.
Albert, M.
Rebeck, G. W.
Gomez-Isla, T.
Clatworthy, A.
Binetti, G.
Hock, C.
Mueller-Thomsen, T.
Mann, U.
Zuchowski, K.
Beisiegel, U.
Staehelin, H.
Growdon, J. H.
Tanzi, R. E.
Hyman, B. T.

August 2017

α2-Macroglobulin (A2M) is a proteinase inhibitor found in association with senile plaques (SP) in Al...

Alpha2-macroglobulin polymorphisms in Italian sporadic and familial Alzheimer's disease

Nacmias, B
Tedde, A
Cellini, E
Forleo, P
Guarnieri, B
Petruzzi, C
D'Andrea, F
Serio, A
Sorbi, S.
ORLACCHIO, ANTONIO

February 2001

A 5-bp deletion and a Val1000 polymorphism at the alpha(2)-macroglobulin (A2M) gene have recently be...

alfa2-Macroglobulin deletion polymorphism and plasma levels in late-onset Alzheimer’s disease

Scacchi, R.
Ruggeri, M.
Gambina, G
Martini, M. C.
Corbo, Rosa Maria

January 2002

The acute-phase "panproteinase" inhibitor "2-macroglobulin (alpha2M), a protein involved in inflamma...

No association between the alpha2-macroglobulin (A2M) deletion and Alzheimer's disease, and no change in A2M mRNA, protein, or protein expression

Blennow, K
Ricksten, A
Prince, J A
Brookes, A J
Emahazion, T
Wasslavik, C
Bogdanovic, N
Andreasen, N
Batsman, S
Marcusson, J
Nägga, Katarina
Wallin, A
Regland, B
Olofsson, H
Hesse, C
Davidsson, P
Minthon, Lennart
Jansson, A
Palmqvist, L
Rymo, L

January 2000

A polymorphism consisting of a deletion near the 5' splice site of exon 18 on the alpha2-macroglobul...

Analysis of genome-wide association studies of Alzheimer disease and of Parkinson disease to determine if these 2 diseases share a common genetic risk

Escott-Price, Valentina
Harold, Denise
Russo, Giancarlo
Vedernikov, Alexey
Sharma, Manu
Saad, Mohamad
Holmans, Peter Alan
Bras, Jose M.
Bettella, Francesco
Keller, Margaux F.
Nicolaou, Nayia
Simón-Sánchez, Javier
Gibbs, J. Raphael
Schulte, Claudia
Durr, Alexandra
Guerreiro, Rita
Hernandez, Dena
Brice, Alexis
Stefánsson, Hreinn
Majamaa, Kari
Gasser, Thomas
Heutink, Peter
Wood, Peter
Martinez, Maria
Singleton, Andrew B.
Nalls, Michael A.
Hardy, John
Owen, Michael John
O’Donovan, Michael Conlon
Williams, Julie
Morris, Huw
Williams, Nigel Melville

January 2013

.Importance Despite Alzheimer disease (AD) and Parkinson disease (PD) being clinically distinct enti...

Sequence variation in the proximity of IDE may impact age at onset of both Parkinson disease and Alzheimer disease

Blomqvist, MEL
Silburn, PA
Buchanan, DD
Andreasen, N
Blennow, K
Pedersen, NL
Brookes, AJ
Mellick, GD
Prince, JA

January 2004

We recently reported that a linkage disequilibrium (LD) block on chromosome 10q encompassing the gen...

Increased susceptibility to sporadic Parkinson's disease by a certain combined alpha-synuclein/apolipoprotein E genotype.

Krüger, Rejko
Vieira-Saecker, A. M.
Kuhn, W.
Berg, D.
Muller, T.
Kuhnl, N.
Fuchs, G. A.
Storch, A.
Hungs, M.
Woitalla, D.
Przuntek, H.
Epplen, J. T.
Schols, L.
Riess, O.

January 1999

Parkinson's disease (PD) is one of the most common neurodegenerative disorders affecting about 1% of...

Genomewide Association Study for Onset Age in Parkinson Disease

Latourelle, Jeanne C.
Pankratz, Nathan
Dumitriu, Alexandra
Wilk, Jemma B.
Goldwurm, Stefano
Pezzoli, Gianni
Mariani, Claudio B.
DeStefano, Anita L.
Halter, Cheryl
Gusella, James F.
Nichols, William C.
Myers, Richard H.
Foroud, Tatiana

September 2009

BACKGROUND: Age at onset in Parkinson disease (PD) is a highly heritable quantitative trait for whic...

The α2-macroglobulin gene in AD: a population-based study and meta-analysis

Koster, MN
Dermaut, Bart
Cruts, M
Houwing-Duistermaat, JJ
Roks, G
Tol, J
Ott, A
Hofman, A
Munteanu, G
Breteler, MMB
van Duijn, CM
Van Broeckhoven, C

January 2000

Background: Whereas several authors recently reported a positive association between the alpha 2-mac...

Modulation of disease risk according to a cathepsin D / apolipoprotein E genotype in Parkinson's disease.

Schulte, T.
Bohringer, S.
Schols, L.
Muller, T.
Fischer, C.
Riess, O.
Przuntek, H.
Berger, K.
Epplen, J. T.
Krüger, Rejko

January 2003

peer reviewedAspartyl protease Cathepsin D (CTSD) has been suggested to play a role in the pathogene...

No association between the alpha-2 macroglobulin I1000V polymorphism and Alzheimer's disease

Wavrant-DeVrieze, F.
Rudrasingham, V.
Lambert, J. C.
Chakraverty, S.
Kehoe, P.
Crook, R.
Amouyel, P.
Wu, W.
Holmans, Peter Alan
Rice, Frances
Perez-Tur, J.
Frigard, B.
Morric, J. C.
Carty, S.
Cottel, D.
Tunstall, N.
Lovestone, S.
Petersen, R. C.
Chartier-Harlin, M. C.
Goate, A.
Owen, Michael John
Williams, Julie
Hardy, J.

March 1999

Recent reports have suggested that variability in the alpha2-macroglobulin gene is a genetic risk fa...

Genetic predisposition to weight loss and regain with lifestyle intervention: Analyses from the Diabetes Prevention Program and the Look AHEAD randomized controlled trials.

Papandonatos, G.D.
Pan, Q.
Pajewski, N.M.
Delahanty, L.M.
Peter, I.
Erar, B.
Ahmad, S.
Harden, M.
Chen, L.
Fontanillas, P.
GIANT Consortium (Albrecht, E.
Wagenknecht, L.E.
Kahn, S.E.
Wing, R.R.
Jablonski, K.A.
Huggins, G.S.
Knowler, W.C.
Florez, J.C
McCaffery, J.M.
Franks, P.W.
Diabetes Prevention Program ()
Look AHEAD Research Group ()

January 2015

We investigated the genetic overlap between Alzheimer’s disease (AD) and Parkinson’s dis...

Genetic overlap between Alzheimer's disease and Parkinson's disease at the MAPT locus.

Desikan, RS
Schork, AJ
Wang, Y
Witoelar, A
Sharma, M
McEvoy, LK
Holland, D
Brewer, JB
Chen, C-H
Thompson, WK
Harold, D
Williams, J
Owen, MJ
O'Donovan, MC
Pericak-Vance, MA
Mayeux, R
Haines, JL
Farrer, LA
Schellenberg, GD
Heutink, P
Singleton, AB
Brice, A
Wood, NW
Hardy, J
Martinez, M
Choi, SH
DeStefano, A
Ikram, MA
Bis, JC
Smith, A
Fitzpatrick, AL
Launer, L
van Duijn, C
Seshadri, S
Ulstein, ID
Aarsland, D
Fladby, T
Djurovic, S
Hyman, BT
Snaedal, J
Stefansson, H
Stefansson, K
Gasser, T
Andreassen, OA
Dale, AM
ADNI, ADGC, GERAD, CHARGE and IPDGC Investigators

December 2015

We investigated the genetic overlap between Alzheimer's disease (AD) and Parkinson's disease (PD). U...

Rare variants in beta-Amyloid precursor protein (APP) and Parkinson's disease.

Schulte EC
Fukumori A
Mollenhauer B
Hor H
Arzberger T
Perneczky R
Kurz A
Diehl-Schmid J
Hull M
Lichtner P
Eckstein G
Zimprich A
Haubenberger D
Pirker W
Brucke T
Bereznai Benjamin
Molnar Mária Judit
Lorenzo-Betancor O
Pastor P
Peters A
Gieger C
Estivill X
Meitinger T
Kretzschmar HA
Trenkwalder C
Haass C
Winkelmann J

March 2019

Many individuals with Parkinson's disease (PD) develop cognitive deficits, and a phenotypic and mole...

Genetic analysis of the alpha2-macroglobulin gene in early- and late-onset Parkinson's disease.

Abstract

Extracted data

Genetic analysis of the alpha2-macroglobulin gene in early- and late-onset Parkinson's disease.

Abstract

Extracted data

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