Discriminative power of different nonmotor signs in early Parkinson's disease. A case-control study
- Diederich, Nico
- Pieri, Vannina
- Hipp, Geraldine
- Rufra, Olivier
- Blyth, Sara
- Vaillant, Michel
DOIAbstract
peer reviewedThe objective of this study was to evaluate the discriminative power of different nonmotor signs for early diagnosis of Parkinson's disease (PD). Thirty patients with PD with <or=3 years of disease duration were compared with 30 healthy controls. Six deficit domains (DD) were defined: hyposmia, sleep abnormalities, dysautonomia, visual deficits, executive dysfunction, and depression. Plotting of Receiver operating characteristic (ROC) curves and exact conditional logistic modeling, followed by manual stepwise descending procedure were used to identify a model for nonmotor signs that detects early PD. Patients with PD and controls did not differ in terms of age, gender, and educational level. Several DD discriminated patients wi...
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